Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR1497)
Drug Name
Solifenacin succinate
Synonyms
Solifenacin (Succinate); Solifenacin succinate; Solifenacin succinate [USAN]; Solifenacin (INN); Solifenacin [INN:BAN]; Soliten; UNII-A8910SQJ1U; [(8R)-1-azabicyclo[2.2.2]octan-8-yl] (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate; ((8r)-1-azabicyclo(2.2.2)octan-8-yl) (1s)-1-phenyl-3,4-dihydro-1h-isoQUINOLINE-2-carboxylate; (+)-Solifenacin; (3R)-1-azabicyclo[2.2.2]octan-3-yl (1S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; 242478-37-1; A8910SQJ1U; AC1L4BM3; CHEMBL1734; NCGC00168778-01; SCHEMBL188493; SCHEMBL9971260; UNII-KKA5DLD701; Vesikur; YM 905; 1-Azabicyclo[2.2.2]octan-8-yl (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate butanedioic acid; 242478-38-2; Butanedioic acid, compd with (1S)-(3R)-1-azabicyclo(2.2.2)oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate (1:1); KKA5DLD701
Indication Overactive bladder [ICD11: GC50] Approved [1]
Structure
3D MOL is unavailable 2D MOL
Pharmaceutical Properties Molecular Weight 480.6 Topological Polar Surface Area 107
Heavy Atom Count 35 Rotatable Bond Count 6
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 7
Cross-matching ID
PubChem CID
216457
ChEBI ID
CHEBI:32151
CAS Number
242478-38-2
TTD Drug ID
D0L4YD
Formula
C27H32N2O6
Canonical SMILES
C1CN2CCC1C(C2)OC(=O)N3CCC4=CC=CC=C4C3C5=CC=CC=C5.C(CC(=O)O)C(=O)O
InChI
1S/C23H26N2O2.C4H6O4/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19;5-3(6)1-2-4(7)8/h1-9,18,21-22H,10-16H2;1-2H2,(H,5,6)(H,7,8)/t21-,22-;/m0./s1
InChIKey
RXZMMZZRUPYENV-VROPFNGYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
4R-hydroxy solifenacin DM006359
131770038
Oxidation - Hydrolyzationn 1 [2]
4R-hydroxy-N-oxide solifenacin DM006360 N. A. Unclear 1 [2]
N-glucuronide Solifenacin DM006362 N. A. Conjugation - Glucuronidation 1 [2]
N-oxide Solifenacin DM006361
29987059
Unclear 1 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR006826 Solifenacin succinate 4R-hydroxy solifenacin Oxidation - Hydrolyzationn CYP3A4 ... [2]
MR006827 Solifenacin succinate 4R-hydroxy-N-oxide solifenacin Unclear Unclear [2]
MR006828 Solifenacin succinate N-oxide Solifenacin Unclear Unclear [2]
MR006829 Solifenacin succinate N-glucuronide Solifenacin Conjugation - Glucuronidation Unclear [2]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 1A1 (CYP1A1) DME0006 Homo sapiens
CP1A1_HUMAN
1.14.14.1
[2]
Cytochrome P450 2D6 (CYP2D6) DME0009 Homo sapiens
CP2D6_HUMAN
1.14.14.1
[2]
Cytochrome P450 3A4 (CYP3A4) DME0001 Homo sapiens
CP3A4_HUMAN
1.14.14.55
[2]
References
1 Solifenacin Succinate was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Clinical pharmacokinetics and pharmacodynamics of solifenacin. Clin Pharmacokinet. 2009;48(5):281-302.

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