Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2081)
Drug Name
D-glucose
Synonyms
Cartose Cerelose; Clearsweet 95; Clintose L; D-Glcp; D-Glucopyranose; D-Glucopyranose, anhydrous; D-Glucopyranoside; D-Glucose; D-glucose-ring; Glc-OH; Glucodin; Glucopyranose; Glucopyranose, D-; Glucopyranoside; Glucose; Glucose 40; Meritose; Meritose 200; Roferose ST; Staleydex 130; Staleydex 95M; glc-ring; nchembio867-comp4; (3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol; 2280-44-6; 2h-pyran-2,3,4,5-tetraol; CHEBI:4167; CPC hydrate; D-Glc; DSSTox_CID_2910; EINECS 218-914-5; Glc
Indication Discovery agent Investigative [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 180.16 Topological Polar Surface Area 110
Heavy Atom Count 12 Rotatable Bond Count 1
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 6
Cross-matching ID
PubChem CID
5793
PubChem SID
3333 ; 819111 ; 823016 ; 823057 ; 833240 ; 838951 ; 841535 ; 7847077 ; 8023353 ; 8153564 ; 14720288 ; 15120604 ; 15147309 ; 22387980 ; 22396026 ; 29218051 ; 29224827 ; 40439603 ; 48415870 ; 48416720 ; 56311091 ; 56311268 ; 56311363 ; 56311402 ; 56311555 ; 56311961 ; 56312072 ; 56314074 ; 56314202 ; 56314360 ; 56475096 ; 79376410 ; 85267087 ; 85301111 ; 87570266 ; 103825436 ; 104243011 ; 104310274 ; 117392201 ; 117689413 ; 126523020 ; 126678536 ; 127264014 ; 127264015 ; 127264016 ; 127264017 ; 127264018 ; 127264019 ; 127264020 ; 127264021
ChEBI ID
CHEBI:4167
CAS Number
2280-44-6
TTD Drug ID
D0C1FY
Formula
C6H12O6
Canonical SMILES
C(C1C(C(C(C(O1)O)O)O)O)O
InChI
1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1
InChIKey
WQZGKKKJIJFFOK-GASJEMHNSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
D-glucuronate DM003133 N. A. Unclear 1 [5]
Glucose-6-phosphate DM004099
5958
Unclear 1 [10]
PYR DM000331
107735
Unclear 1 [14]
L-Gulonate DM005863
6857680
Unclear 2 [5]
Ascorbic acid DM004934
54670067
Unclear 3 [5]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR006271 D-glucose D-glucuronate Unclear AKR1A ... [5]
MR006274 D-glucose Glucose-6-phosphate Unclear HK [10]
MR006275 D-glucose Pyruvate Unclear Unclear [14]
MR006272 D-glucuronate L-Gulonate Unclear Unclear [5]
MR006273 L-Gulonate L-Ascorbate Unclear Unclear [5]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
ADP-dependent glucokinase (ADPGK) DME0475 Homo sapiens
ADPGK_HUMAN
2.7.1.147
[2]
Alcohol dehydrogenase (ADH) DME1317 Lactobacillus reuteri
A4L2V0_LACRE
1.1.1.1
[3] , [4]
Aldo-keto reductase 1B1 (AKR1B1) DME0087 Homo sapiens
ALDR_HUMAN
1.1.1.21
[5]
Aldo-keto reductase family 1 member A (AKR1A) DMEN315 Homo sapiens Not Available Not Available [5]
Alpha-glucosidase (aglA) DME1299 Lactobacillus paracasei
PAGL1_LACP3
3.2.1.20
[6]
Brain form hexokinase (HK1) DME0476 Homo sapiens
HXK1_HUMAN
2.7.1.1
[7]
D-Lactate dehydrogenase (ldhA) DME1116 Megasphaera elsdenii
A0A1C7BXR3_PSEAI
1.1.1.28
[8] , [9]
hexokinase (HK) DMEN277 Homo sapiens Not Available Not Available [10]
Unclear metabolic mechanism (DME-unclear) DME1267 Anaerobutyricum hallii Not Available Not Available [11]
Unclear metabolic mechanism (DME-unclear) DME1357 Alistipes indistinctus Not Available Not Available [12]
Unclear metabolic mechanism (DME-unclear) DME1359 Anaerostipes caccae Not Available Not Available [13]
⏷ Show the Full List of 11  DME(s)
Experimental Enzyme Kinetic Data of This Drug
DME Name DME Info Kinetic Data Uniprot ID REF
ADP-dependent glucokinase (ADPGK) DME0475 Km = 0.27 microM
ADPGK_HUMAN
[2]
Brain form hexokinase (HK1) DME0476 Km = 0.057 microM
HXK1_HUMAN
[7]
References
1 The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY. Nucleic Acids Res. 2020 Jan 8;48(D1):D1006-D1021. (Ligand id: 4536).
2 The Structural and functional characterization of mammalian ADP-dependent glucokinase. J Biol Chem. 2016 Feb 19;291(8):3694-704.
3 1,3-Propanediol:NAD+ oxidoreductases of Lactobacillus brevis and Lactobacillus buchneri. Appl Environ Microbiol. 1992 Jun;58(6):2005-10.
4 Aciduric strains of Lactobacillus reuteri and Lactobacillus rhamnosus, isolated from human feces, have strong adhesion and aggregation properties. Probiotics Antimicrob Proteins. 2018 Mar;10(1):89-97.
5 Pleiotropic Actions of Aldehyde Reductase (AKR1A)
6 Administration of Lactobacillus paracasei ameliorates type 2 diabetes in mice. Food Funct. 2018 Jul 17;9(7):3630-3639.
7 Nonaggregating mutant of recombinant human hexokinase I exhibits wild-type kinetics and rod-like conformations in solution. Biochemistry. 1999 Jun 29;38(26):8359-66.
8 Presence of lactate dehydrogenase and lactate racemase in Megasphaera elsdenii grown on glucose or lactate. Appl Environ Microbiol. 1993 Jan;59(1):255-9.
9 hole-Genome sequence of a Megasphaera elsdenii strain isolated from the gut of a healthy Indian adult subject. Genome Announc. 2017 Oct 19;5(42):e01033-17.
10 Glucagon and regulation of glucose metabolism
11 Reclassification of Eubacterium hallii as Anaerobutyricum hallii gen. nov., comb. nov., and description of Anaerobutyricum soehngenii sp. nov., a butyrate and propionate-producing bacterium from infant faeces. Int J Syst Evol Microbiol. 2018 Dec;68(12):3741-3746.
12 Alistipes indistinctus sp. nov. and Odoribacter laneus sp. nov., common members of the human intestinal microbiota isolated from faeces. Int J Syst Evol Microbiol. 2010 Jun;60(Pt 6):1296-302.
13 Anaerostipes caccae gen. nov., sp. nov., a new saccharolytic, acetate-utilising, butyrate-producing bacterium from human faeces. Syst Appl Microbiol. 2002 Apr;25(1):46-51.
14 DrugBank(Pharmacology-Metabolism):D-glucose

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