Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1357)
DME Name Unclear metabolic mechanism (DME-unclear), Alistipes indistinctus
Gene Name DME-unclear
Lineage    Species: Alistipes indistinctus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Rikenellaceae
Genus: Alistipes
Species: Alistipes indistinctus
Subspecies: Alistipes indistinctus DSM 22520
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:        24 Drugs
Mycophenolate mofetil
 Drug Info Approved Crohn disease ICD11: DD70 [1]
Tacrolimus
 Drug Info Approved Ulcerative colitis ICD11: DD71 [1]
Deflazacort
 Drug Info Approved Muscular dystrophy ICD11: 8C70 [1]
Norethindrone acetate
 Drug Info Approved Menorrhagia ICD11: GA20 [1]
Ziprasidone
 Drug Info Approved Schizophrenia ICD11: 6A20 [1]
Cyclophosphamide
 Drug Info Approved Multiple myeloma ICD11: 2A83 [1]
Diltiazem hydrochloride
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Fluoxetine hydrochloride
 Drug Info Approved Depression ICD11: 6A71 [1]
Riluzole
 Drug Info Approved Amyotrophic lateral sclerosis ICD11: 8B60 [1]
Danazol
 Drug Info Approved Endometriosis ICD11: GA10 [1]
Famciclovir
 Drug Info Approved Genital herpes ICD11: 1A94 [1]
Omeprazole
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Sulfasalazine
 Drug Info Approved Rheumatoid arthritis ICD11: FA20 [1]
Vilazodone hydrochloride
 Drug Info Approved Depression ICD11: 6A71 [1]
Loperamide hydrochloride
 Drug Info Approved Irritable bowel syndrome ICD11: DD91 [1]
Pantoprazole sodium
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Bromocriptine mesylate
 Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Entacapone
 Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Melphalan
 Drug Info Approved Multiple myeloma ICD11: 2A83 [1]
Paliperidone
 Drug Info Approved Bipolar disorder ICD11: 6A60 [1]
Tinidazole
 Drug Info Approved Protozoan infection ICD11: 1F5Z [1]
Risperidone
 Drug Info Approved Schizophrenia ICD11: 6A20 [1]
Cetirizine
 Drug Info Approved Allergy ICD11: 4A80 [1]
Diflorasone diacetate
 Drug Info Approved Rosacea ICD11: ED90 [1]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          7 Drugs
Artemisinin
 Drug Info Phase 4 Malaria ICD11: 1F40 [1]
Phenazopyridine
 Drug Info Phase 4 Infectious cystitis ICD11: GC00 [1]
Idebenone
 Drug Info Phase 4 Mitochondrial myopathy ICD11: 8C73 [1]
Trimebutine
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
Pericyazine
 Drug Info Phase 4 Anxiety disorder ICD11: 6B00 [1]
Racecadotril
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
Bisacodyl
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          3 Drugs
Roxatidine
 Drug Info Phase 2 Gastro-oesophageal reflux disease ICD11: DA22 [1]
TU-199
 Drug Info Phase 2 Gastro-oesophageal reflux disease ICD11: DA22 [1]
BRN-0889798
 Drug Info Phase 2 Keratoconjunctivitis sicca ICD11: 9A79 [1]
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          2 Drugs
CB-3304
 Drug Info Phase 1/2 Chronic lymphocytic leukaemia ICD11: 2A82 [1]
BRN-0498823
 Drug Info Phase 1 Essential hypertension ICD11: BA00 [1]
      Discontinued/withdrawn Drugs Click to Show/Hide the Full List of Drugs:          1 Drugs
WIN-4692
 Drug Info Discontinued Cerebral vasospasm ICD11: BA85 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          2 Drugs
D-glucose
 Drug Info Investigative Discovery agent ICD: N.A. [2]
Diacetamate
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
2 Alistipes indistinctus sp. nov. and Odoribacter laneus sp. nov., common members of the human intestinal microbiota isolated from faeces. Int J Syst Evol Microbiol. 2010 Jun;60(Pt 6):1296-302.

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