Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2082)
Drug Name
D-glucose 1-phosphate
Synonyms
CIX3U01VAU; D-Glucose alpha-1-phosphate; Glucos P; Glucose 1-(dihydrogen phosphate); Glucose monophosphate; Glucose-1-phosphate; alpha-glucose-1-phosphate; .alpha.-D-Glucopyranose, 1-(dihydrogen phosphate); 1-O-phosphono-alpha-D-glucopyranose; 59-56-3; CHEBI:29042; G1P; HXXFSFRBOHSIMQ-VFUOTHLCSA-N; UNII-CIX3U01VAU; alpha-D-Glucopyranose, 1-(dihydrogen phosphate); alpha-D-Glucopyranosyl phosphate; alpha-D-Glucose 1-phosphate; alpha-D-glucose-1-phosphate
Indication Discovery agent Investigative [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 260.14 Topological Polar Surface Area 157
Heavy Atom Count 16 Rotatable Bond Count 3
Hydrogen Bond Donor Count 6 Hydrogen Bond Acceptor Count 9
Cross-matching ID
PubChem CID
65533
ChEBI ID
CHEBI:29042
CAS Number
59-56-3
Formula
C6H13O9P
Canonical SMILES
C(C1C(C(C(C(O1)OP(=O)(O)O)O)O)O)O
InChI
1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5-,6-/m1/s1
InChIKey
HXXFSFRBOHSIMQ-VFUOTHLCSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Glucose-6-phosphate DM004099
5958
Unclear 1 [2]
UDP-glc DM004097
8629
Unclear 1 [2]
Glucogen DM005865 N. A. Unclear 2 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR006276 D-glucose 1-phosphate Glucose-6-phosphate Unclear PGM2 [2]
MR006277 D-glucose 1-phosphate UDP-glc Unclear Unclear [2]
MR006278 UDP-glc Glucogen Unclear Unclear [2]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Phosphoglucomutase 2 (PGM2) DMEN317 Saccharomyces cerevisiae
PGM2_YEAST
5.4.2.2
[2]
Phosphomannomutase 1 (PMM1) DME0453 Homo sapiens
PMM1_HUMAN
5.4.2.8
[3]
Phosphomannomutase 2 (PMM2) DME0452 Homo sapiens
PMM2_HUMAN
5.4.2.8
[3]
UDP-glucose pyrophosphorylase (UGPase) DME0514 Homo sapiens
UGPA_HUMAN
2.7.7.9
[4]
Experimental Enzyme Kinetic Data of This Drug
DME Name DME Info Kinetic Data Uniprot ID REF
Phosphomannomutase 1 (PMM1) DME0453 Km = 0.0075 microM
PMM1_HUMAN
[3]
Phosphomannomutase 2 (PMM2) DME0452 Km = 0.0075 microM
PMM2_HUMAN
[3]
UDP-glucose pyrophosphorylase (UGPase) DME0514 Km = 0.067 microM
UGPA_HUMAN
[4]
References
1 DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (id: DB02843)
2 Intracellular glucose 1-phosphate and glucose 6-phosphate levels modulate Ca2+ homeostasis in Saccharomyces cerevisiae
3 The X-ray crystal structures of human alpha-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1a. J Biol Chem. 2006 May 26;281(21):14918-26.
4 The crystal structure of human UDP-glucose pyrophosphorylase reveals a latch effect that influences enzymatic activity. Biochem J. 2012 Mar 1;442(2):283-91.

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