Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN317)
DME Name Phosphoglucomutase 2 (PGM2), Saccharomyces cerevisiae
Gene Name PGM2
UniProt ID
PGM2_YEAST
EC Number    EC: 5.4.2.2     (Click to Show/Hide the Complete EC Tree)
Isomerase
Mutase
Phosphomutase
EC: 5.4.2.2
Lineage    Species: Saccharomyces cerevisiae     (Click to Show/Hide the Complete Species Lineage)
Kingdom: .
Phylum: .
Class: .
Order: .
Family: .
Genus: .
Species: Saccharomyces cerevisiae
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MSFQIETVPTKPYEDQKPGTSGLRKKTKVFKDEPNYTENFIQSIMEAIPEGSKGATLVVG
GDGRYYNDVILHKIAAIGAANGIKKLVIGQHGLLSTPAASHIMRTYEEKCTGGIILTASH
NPGGPENDMGIKYNLSNGGPAPESVTNAIWEISKKLTSYKIIKDFPELDLGTIGKNKKYG
PLLVDIIDITKDYVNFLKEIFDFDLIKKFIDNQRSTKNWKLLFDSMNGVTGPYGKAIFVD
EFGLPADEVLQNWHPSPDFGGMHPDPNLTYASSLVKRVDREKIEFGAASDGDGDRNMIYG
YGPSFVSPGDSVAIIAEYAAEIPYFAKQGIYGLARSFPTSGAIDRVAKAHGLNCYEVPTG
WKFFCALFDAKKLSICGEESFGTGSNHVREKDGVWAIMAWLNILAIYNKHHPENEASIKT
IQNEFWAKYGRTFFTRYDFEKVETEKANKIVDQLRAYVTKSGVVNSAFPADESLKVTDCG
DFSYTDLDGSVSDHQGLYVKLSNGARFVLRLSGTGSSGATIRLYIEKYCDDKSQYQKTAE
EYLKPIINSVIKFLNFKQVLGTEEPTVRT
Function Major phosphoglucomutase isozyme that catalyzes the reversible interconversion of glucose 1-phosphate and glucose 6-phosphate . Constitutes about 80-90% of the phosphoglucomutase activity in the cell . Key enzyme in hexose metabolism. The forward reaction is an essential step in the energy metabolism of galactose since the product of the galactose pathway enzymes in yeast is glucose 1-phosphate. The reverse reaction is an essential step for biosynthesis when carbon sources other than galactose are the energy source because glucose 1-phosphate is the starting point for the synthesis of UDP-glucose, which acts as a precursor for the synthesis of oligosaccharides and trehalose .
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          3 Drugs
GDP-alpha-D-glucose
 Drug Info Investigative Discovery agent ICD: N.A. [1]
D-glucose 1-phosphate
 Drug Info Investigative Discovery agent ICD: N.A. [1]
D-glucose 6-phosphate
 Drug Info Investigative Discovery agent ICD: N.A. [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR006276 D-glucose 1-phosphate Glucose-6-phosphate Unclear - Unclear D-glucose 1-phosphate [1]
MR006279 D-glucose 6-phosphate Glucose-1-phosphate Unclear - Unclear D-glucose 6-phosphate [1]
MR006326 D-glucose 1-phosphate Glucose-6-phosphate Unclear - Unclear GDP-alpha-D-glucose [1]
References
1 Intracellular glucose 1-phosphate and glucose 6-phosphate levels modulate Ca2+ homeostasis in Saccharomyces cerevisiae

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