Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2292)
Drug Name
Memantine
Synonyms Memantine (extended release); Memantine ER; Namenda XR; Memantine (extended release), Forest
Indication Alzheimer disease [ICD11: 8A20] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 179.3 Topological Polar Surface Area 26
Heavy Atom Count 13 Rotatable Bond Count 0
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 1
Cross-matching ID
PubChem CID
4054
PubChem SID
586325 ; 598200 ; 3221249 ; 6380039 ; 7737264 ; 8149719 ; 8152542 ; 11167042 ; 11335243 ; 11360482 ; 11363501 ; 11366063 ; 11368625 ; 11372025 ; 11374681 ; 11376787 ; 11461454 ; 11467006 ; 11468126 ; 11485192 ; 11486662 ; 11489224 ; 11490738 ; 11492836 ; 11494421 ; 15147301 ; 24310548 ; 26751885 ; 29223165 ; 46506702 ; 47290972 ; 47290973 ; 47440080 ; 47515155 ; 47662108 ; 47736297 ; 47736298 ; 48184834 ; 48259056 ; 48334316 ; 49698917 ; 50057972 ; 50104569 ; 53790630 ; 57322117 ; 74530305 ; 90341818 ; 96024864 ; 99301156 ; 103211988
ChEBI ID
CHEBI:64312
CAS Number
19982-08-2
TTD Drug ID
D01JEU
Formula
C12H21N
Canonical SMILES
CC12CC3CC(C1)(CC(C3)(C2)N)C
InChI
1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3
InChIKey
BUGYDGFZZOZRHP-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
1-Nitroso-3,5-dimethyladamantane DM001104
87444617
Oxidation - Deamination 1 [3]
Memantine N-glucuronide metabolite DM001105 N. A. Conjugation - N-Glucuronidation 1 [3]
Memantine-d6 Hydrochloride DM001103
71749943
Oxidation - 6-Hydroxylation 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR002924 Memantine Memantine-d6 Hydrochloride Oxidation - 6-Hydroxylation Unclear [3]
MR002925 Memantine 1-Nitroso-3,5-dimethyladamantane Oxidation - Deamination Unclear [3]
MR002926 Memantine Memantine N-glucuronide metabolite Conjugation - N-Glucuronidation Unclear [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Unclear metabolic mechanism (DME-unclear) DME1391 Bifidobacterium ruminatum Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1431 Holdemanella biformis Not Available Not Available [2]
References
1 Memantine was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
3 Namenda Monograph, Canadian

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