Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1431)
DME Name Unclear metabolic mechanism (DME-unclear), Holdemanella biformis
Gene Name DME-unclear
Lineage    Species: Holdemanella biformis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Erysipelotrichia
Order: Erysipelotrichales
Family: Erysipelotrichaceae
Genus: Holdemanella
Species: Holdemanella biformis
Subspecies: Holdemanella biformis DSM 3989
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:        35 Drugs
Mycophenolate mofetil
 Drug Info Approved Crohn disease ICD11: DD70 [1]
Tacrolimus
 Drug Info Approved Ulcerative colitis ICD11: DD71 [1]
Carvedilol
 Drug Info Approved Congestive heart failure ICD11: BD10 [1]
Drospirenone
 Drug Info Approved Contraception ICD11: JA65 [1]
Levonorgestrel
 Drug Info Approved Menorrhagia ICD11: GA20 [1]
Norethindrone acetate
 Drug Info Approved Menorrhagia ICD11: GA20 [1]
Cyclophosphamide
 Drug Info Approved Multiple myeloma ICD11: 2A83 [1]
Fluoxetine hydrochloride
 Drug Info Approved Depression ICD11: 6A71 [1]
Budesonide
 Drug Info Approved Allergic rhinitis ICD11: CA08 [1]
Danazol
 Drug Info Approved Endometriosis ICD11: GA10 [1]
Glipizide
 Drug Info Approved Diabetes mellitus ICD11: 5A10 [1]
Indapamide
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Omeprazole
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Ramipril
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Sulfasalazine
 Drug Info Approved Rheumatoid arthritis ICD11: FA20 [1]
Tolazamide
 Drug Info Approved Diabetes mellitus ICD11: 5A10 [1]
Clemastine fumarate
 Drug Info Approved Pulmonary oedema ICD11: CB01 [1]
Loperamide hydrochloride
 Drug Info Approved Irritable bowel syndrome ICD11: DD91 [1]
Lovastatin
 Drug Info Approved Hypertriglyceridaemia ICD11: 5C80 [1]
Memantine
 Drug Info Approved Alzheimer disease ICD11: 8A20 [1]
Pantoprazole sodium
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Celecoxib
 Drug Info Approved Rheumatoid arthritis ICD11: FA20 [1]
Enalapril
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Entacapone
 Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Melphalan
 Drug Info Approved Multiple myeloma ICD11: 2A83 [1]
Penbutolol
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Quinapril
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Tinidazole
 Drug Info Approved Protozoan infection ICD11: 1F5Z [1]
Trandolapril
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Anagrelide hydrochloride
 Drug Info Approved Thrombocytosis ICD11: 3B63 [1]
Norgestimate
 Drug Info Approved Acne vulgaris ICD11: ED80 [1]
Olmesartan medoxomil
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Oxybutynin chloride
 Drug Info Approved Overactive bladder ICD11: GC50 [1]
Risperidone
 Drug Info Approved Schizophrenia ICD11: 6A20 [1]
Cetirizine
 Drug Info Approved Allergy ICD11: 4A80 [1]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          5 Drugs
Famprofazone
 Drug Info Phase 4 Anaesthesia ICD11: 8E22 [1]
Artemisinin
 Drug Info Phase 4 Malaria ICD11: 1F40 [1]
Phenazopyridine
 Drug Info Phase 4 Infectious cystitis ICD11: GC00 [1]
Trimebutine
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
Bisacodyl
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          2 Drugs
TU-199
 Drug Info Phase 2 Gastro-oesophageal reflux disease ICD11: DA22 [1]
BRN-0889798
 Drug Info Phase 2 Keratoconjunctivitis sicca ICD11: 9A79 [1]
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          2 Drugs
CB-3304
 Drug Info Phase 1/2 Chronic lymphocytic leukaemia ICD11: 2A82 [1]
BRN-0498823
 Drug Info Phase 1 Essential hypertension ICD11: BA00 [1]
      Discontinued/withdrawn Drugs Click to Show/Hide the Full List of Drugs:          1 Drugs
WIN-4692
 Drug Info Discontinued Cerebral vasospasm ICD11: BA85 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Diacetamate
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.

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