Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2677)
Drug Name
Ginsenoside Rc
Synonyms
Ginsenoside Rc; Panaxoside RC; ginsenoside-Rc; 0K83B0L786; 11021-14-0; 20-((6-O-alpha-L-Arabinofuranosyl-beta-D-glucopyranosyl)oxy)-12beta-hydroxydammar-24-en-3beta-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside; 20-[(6-O-a-L-arabinofuranosyl-ss-D-glucopyranosyl)oxy]-12ss-hydroxydammar-24-en-3ss-yl 2-O-ss-D-glucopyranosyl-ss-D-glucopyranoside; AB0029025; AKOS037514670; AS-56539; BRN 1677618; CHEBI:77154; CHEMBL451702; CS-3837; EINECS 234-253-5; HY-N0042; MFCD00133368; NCGC00485983-01; NSC 310104; UNII-0K83B0L786; s9266
Indication Diabetes mellitus [ICD11: 5A10] Investigative [1]
Structure
3D MOL is unavailable 2D MOL
Pharmaceutical Properties Molecular Weight 1079.3 Topological Polar Surface Area 357
Heavy Atom Count 75 Rotatable Bond Count 16
Hydrogen Bond Donor Count 14 Hydrogen Bond Acceptor Count 22
Cross-matching ID
PubChem CID
12855889
ChEBI ID
CHEBI:77154
CAS Number
11021-14-0
Formula
C53H90O22
Canonical SMILES
CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CCC4C3(CCC(C4(C)C)OC5C(C(C(C(O5)CO)O)O)OC6C(C(C(C(O6)CO)O)O)O)C)C)O)C)OC7C(C(C(C(O7)COC8C(C(C(O8)CO)O)O)O)O)O)C
InChI
1S/C53H90O22/c1-23(2)10-9-14-53(8,75-47-43(67)39(63)37(61)29(72-47)22-68-45-41(65)36(60)28(21-56)69-45)24-11-16-52(7)33(24)25(57)18-31-50(5)15-13-32(49(3,4)30(50)12-17-51(31,52)6)73-48-44(40(64)35(59)27(20-55)71-48)74-46-42(66)38(62)34(58)26(19-54)70-46/h10,24-48,54-67H,9,11-22H2,1-8H3/t24-,25+,26+,27+,28-,29+,30-,31+,32-,33-,34+,35+,36-,37+,38-,39-,40-,41+,42+,43+,44+,45+,46-,47-,48-,50-,51+,52+,53-/m0/s1
InChIKey
JDCPEKQWFDWQLI-LUQKBWBOSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Ginsenoside Re Metabolite Mb DM005898
146160065
Unclear 1 [4]
Ginsenoside Re Metabolite Mc DM005899
9896928
Unclear 1 [4]
CK DM005900
9852086
Unclear 2 [4]
Ginsenoside Re Metabolite Mc DM005899
9896928
Unclear 2 [4]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR006330 Ginsenoside Rc Ginsenoside Re Metabolite Mb Unclear Unclear [4]
MR006332 Ginsenoside Rc Ginsenoside Re Metabolite Mc Unclear Unclear [4]
MR006331 Ginsenoside Re Metabolite Mb Ginsenoside Re Metabolite Mc Unclear Unclear [4]
MR006333 Ginsenoside Re Metabolite Mc CK Unclear Unclear [4]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Beta-glucosidase (bglA) DME1205 Bifidobacterium animalis
A0A4Q4LS82_BIFAN
3.2.1.21
[2]
Beta-glucosidase (bglA) DME1207 Lactobacillus rhamnosus
A0A249DCH3_LACRH
3.2.1.21
[2]
Unclear metabolic mechanism (DME-unclear) DME1392 Bifidobacterium angulatum Not Available Not Available [3]
References
1 Ginsenoside Rc, an active component of Panax ginseng, stimulates glucose uptake in C2C12 myotubes through an AMPK-dependent mechanism. J Ethnopharmacol. 2010 Feb 17;127(3):771-6.
2 Fermentation of protopanaxadiol type ginsenosides (PD) with probiotic Bifidobacterium lactis and Lactobacillus rhamnosus. Appl Microbiol Biotechnol. 2017 Jul;101(13):5427-5437.
3 Interactions between various microbes and ginseng botanicals. Crit Rev Microbiol. 2011 May;37(2):113-20.
4 Pharmacokinetic study of ginsenoside Rc and simultaneous determination of its metabolites in rats using RRLC-Q-TOF-MS

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