Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2753)
Drug Name
Glucose-bisphosphate
Synonyms
Glucose 1,6-bisphosphate; Alpha-D-Glucose 1,6-bisphosphate; 10139-18-1; alpha-D-Glucose 1,6-bis(dihydrogen phosphate); Glucose 1,6-diphosphate; glucose-1,6-bisphosphate; alpha-D-Glucose 1,6-diphosphate; UNII-DRX17R6AM2; D-Glucose 1,6-biphosphate; D-Glucose 1,6-diphosphate; DRX17R6AM2; alpha-D-Glucose 1,6-biphosphate; alpha-D-Glucose-1,6-diphosphate; RWHOZGRAXYWRNX-VFUOTHLCSA-N; alpha-D-glucopyranose, 1,6-bis(dihydrogen phosphate); 1,6-di-O-phosphono-alpha-D-glucopyranose; 2fkf; Glc-1,6P; G16; EINECS 233-395-5; Glucose-1,3-bisphosphate; glucose 1, 6-diphosphate; bmse000087; a-D-Glucose 1,6-diphosphate; a-D-Glucose 1,6-bisphosphate; alpha-Glucose 1,6-diphosphate; delta-Glucose 1,6-diphosphate; SCHEMBL1266885; CHEBI:18148; alpha-D-Glucose-1,6-bisphosphate; ZINC4095589; .alpha.-D-Glucose 1,6-bisphosphate; alpha-delta-Glucose 1,6-diphosphate; alpha-delta-Glucose 1,6-bisphosphate; Glucose 1,6-diphosphate (6CI,7CI); DB02835; a-D-Glucose 1,6-bis(dihydrogen phosphate); C01231; alpha-delta-Glucose 1,6-bis(dihydrogen phosphate); Alpha-D-1,6-bis(dihydrogen phosphate) Glucopyranose; alpha-D-glucopyranose 1,6-bis(dihydrogen phosphate); Q4122197; Alpha-delta-1,6-bis(dihydrogen phosphate) Glucopyranose; .alpha.-D-Glucose 1,6-bisphosphate potassium salt hydrate; FFE24833-162C-479C-90C5-CDF93D1E899A; alpha-D-Glucopyranose, 1,6-bis(dihydrogen phosphate) (9CI); Glucopyranose, 1,6-bis(dihydrogen phosphate), alpha-D- (8CI); {[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[(phosphonooxy)methyl]oxan-2-yl]oxy}phosphonic acid
Indication Discovery agent Investigative [1]
Structure
3D MOL 2D MOL
Cross-matching ID
PubChem CID
82400
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Unclear DM009999 N. A. Unclear 1 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR007004 Glucose-bisphosphate Unclear Unclear GLP [2]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
glucose 1,6-P2 phosphatase (GLP) DMEN341 Bacteroides fragilis Not Available Not Available [2]
L-Lactate dehydrogenase (ldh) DME1512 Lactobacillus casei
LDH_LACCA
1.1.1.27
[3]
Experimental Enzyme Kinetic Data of This Drug
DME Name DME Info Kinetic Data Uniprot ID REF
L-Lactate dehydrogenase (ldh) DME1512 Km = 10 microM
LDH_LACCA
[3]
References
1 Fructose 1,6-bisphosphate inhibits osteoclastogenesis by attenuating RANKL-induced NF-B/NFATc-1. Inflamm Res. 2019 May;68(5):415-421.
2 Bisphosphorylated metabolites of glycerate, glucose, and fructose: functions, metabolism and molecular pathology
3 Purification, properties and immunological relationship of L (+)-lactate dehydrogenase from Lactobacillus casei. Eur J Biochem. 1976 Aug 16;67(2):543-55.

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