Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR5352)
Drug Name
Thiazolidinedione
Synonyms
2295-31-0; 1,3-Thiazolidine-2,4-dione; thiazolidine-2,4-dione; 2,4-Dioxothiazolidine; 2,4(3H,5H)-Thiazoledione; USAF EK-5496; Thiazolidindione; UNII-AA68LXK93C; Thiazolidinedione-2,4; NSC 6745; EINECS 218-941-2; BRN 0110700; AA68LXK93C; AI3-61185; CHEBI:50992; NSC6745; ZOBPZXTWZATXDG-UHFFFAOYSA-N; MFCD00005478; 2,4-Thiazolidinedione, 99%; C3H3NO2S; thiazolidine-dione; 2,4-thiazolidindione; 2,5H)-Thiazoledione; PubChem17487
Indication Alzheimer disease [ICD11: 8A20] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 117.13 Topological Polar Surface Area 71.5
Heavy Atom Count 7 Rotatable Bond Count 0
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 3
Cross-matching ID
PubChem CID
5437
ChEBI ID
CHEBI:50992
CAS Number
2295-31-0
TTD Drug ID
D0K8IX
Formula
C3H3NO2S
Canonical SMILES
C1C(=O)NC(=O)S1
InChI
InChI=1S/C3H3NO2S/c5-2-1-7-3(6)4-2/h1H2,(H,4,5,6)
InChIKey
ZOBPZXTWZATXDG-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
PTC3 DM018743 N. A. Unclear - Unclear 1 [3]
PTC4 DM018746 N. A. Unclear - Unclear 1 [3]
Thiazolidinedione Metabolite M1 DM018739 N. A. Unclear - Unclear 1 [3]
Thiazolidinedione Metabolite M3 DM018745 N. A. Unclear - Unclear 1 [3]
Thiazolidinedione Metabolite M4 DM018744 N. A. Unclear - Unclear 1 [3]
Unclear DM009999 N. A. Unclear - Unclear 1 [3]
PTC1 DM018741 N. A. Unclear - Unclear 2 [3]
PTC2 DM018742 N. A. Unclear - Unclear 2 [3]
PTC5 DM016373
85939716
Unclear - Unclear 2 [3]
PTC6 DM018738 N. A. Unclear - Unclear 2 [3]
Thiazolidinedione Metabolite M2 DM018740 N. A. Unclear - Unclear 2 [3]
⏷ Show the Full List of 11  DM(s)
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR011029 Thiazolidinedione Unclear Unclear - Unclear Unclear [3]
MR011032 Thiazolidinedione Thiazolidinedione Metabolite M1 Unclear - Unclear Unclear [3]
MR011036 Thiazolidinedione PTC3 Unclear - Unclear Unclear [3]
MR011037 Thiazolidinedione Thiazolidinedione Metabolite M4 Unclear - Unclear Unclear [3]
MR011038 Thiazolidinedione Thiazolidinedione Metabolite M3 Unclear - Unclear Unclear [3]
MR011039 Thiazolidinedione PTC4 Unclear - Unclear Unclear [3]
MR011033 Thiazolidinedione Metabolite M1 Thiazolidinedione Metabolite M2 Unclear - Unclear Unclear [3]
MR011030 Unclear PTC5 Unclear - Unclear Unclear [3]
MR011031 Unclear PTC6 Unclear - Unclear Unclear [3]
MR011034 Unclear PTC1 Unclear - Unclear Unclear [3]
MR011035 PTC1 PTC2 Unclear - Unclear Unclear [3]
⏷ Show the Full List of 11 MR(s)
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 2C8 (CYP2C8) DME0018 Homo sapiens
CP2C8_HUMAN
1.14.14.1
[2]
References
1 Thiazolidinediones: a comparative review of approved uses. Diabetes Technol Ther. 2000 Autumn;2(3):429-40.
2 Effect of rifampicin on the pharmacokinetics of pioglitazone
3 Species and gender differences in the formation of an active metabolite of a substituted 2,4-thiazolidinedione insulin sensitizer

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