Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR5398)
Drug Name
Cefuroxime axetil
Prodrug Info Cefuroxime axetil is the prodrug of Free cefuroxime
Synonyms
cefuroxime axetil; Ceftin; Zinnat; Elobact; Zinat; Cefuroxime 1-acetoxyethyl ester; Bioracef; CXM-AX; Coliofossim; Furoxime; Cetoxil; Celocid; Cethixim; Nivador; Medoxm; Kalcef; Zoref; Sharox-500; UNII-Z49QDT0J8Z; DRG-0157; SN 407; CCI 15641; CCI-15641; Cepazine; CCI 1564; BRN 6854419; Z49QDT0J8Z; CHEBI:3516; (RS)-1-Hydroxyethyl (6R,7R)-7-(2-(2-furyl)glyoxylamido)-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate, 7(sup 2)-(Z)-(O-methyloxime), 1-acetate 3-carbamate; C20H22N4O10S; Cefazine; Altacef
Indication Bacterial infection [ICD11: 1A00-1C4Z] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 510.5 Topological Polar Surface Area 214
Heavy Atom Count 35 Rotatable Bond Count 12
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 12
Cross-matching ID
PubChem CID
6321416
ChEBI ID
CHEBI:3516
CAS Number
64544-07-6
Formula
C20H22N4O10S
Canonical SMILES
CC(OC(=O)C)OC(=O)C1=C(CSC2N1C(=O)C2NC(=O)C(=NOC)C3=CC=CO3)COC(=O)N
InChI
InChI=1S/C20H22N4O10S/c1-9(25)33-10(2)34-19(28)15-11(7-32-20(21)29)8-35-18-14(17(27)24(15)18)22-16(26)13(23-30-3)12-5-4-6-31-12/h4-6,10,14,18H,7-8H2,1-3H3,(H2,21,29)(H,22,26)/b23-13-/t10?,14-,18-/m1/s1
InChIKey
KEJCWVGMRLCZQQ-YJBYXUATSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Acetaldehyde DM003092
177
Unclear - Unclear 1 [2]
Acetic acid DM001682
176
Unclear - Unclear 1 [2]
Free cefuroxime DM015466
5479529
Hydrolysis - Hydrolysis 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR008003 Cefuroxime axetil Acetic acid Unclear - Unclear Unclear [2]
MR008004 Cefuroxime axetil Acetaldehyde Unclear - Unclear Unclear [2]
MR008005 Cefuroxime axetil Free cefuroxime Hydrolysis - Hydrolysis Unclear [3]
References
1 Cefuroxime axetil was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019)
2 DrugBank(Pharmacology-Metabolism):Cefuroxime axetil
3 Cefuroxime axetil

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