Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008003)
Formula
SVG example
Unclear
Reactant Cefuroxime axetil Product Acetic acid
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008004 Cefuroxime axetil Acetaldehyde Unclear - Unclear Cefuroxime axetil [1]
MR008005 Cefuroxime axetil Free cefuroxime Hydrolysis - Hydrolysis Cefuroxime axetil [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000046 Acetaldehyde Acetic acid Unclear Acetaldehyde [3], [4], [5]
MR001403 Lactulose Acetic acid Oxidation - N-Dealkylation Lactulose [6]
MR007450 Acetaldehyde Acetic acid Oxidation - Oxidationn Ethanol [7]
MR004211 Acetaldehyde Acetic acid Unclear D-xylulose [8]
MR008929 HEDP Acetic acid Unclear - Unclear Fotemustine [9]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000045 Acetic acid Acetyl-CoA Unclear Acetaldehyde [10], [5], [11]
References
1 DrugBank(Pharmacology-Metabolism):Cefuroxime axetil
2 Cefuroxime axetil
3 Genetic polymorphism in ethanol metabolism: acetaldehyde contribution to alcohol abuse and alcoholism Mol Psychiatry. 2004 Jun;9(6):570-81. doi: 10.1038/sj.mp.4001497.
4 Metabolism of acetaldehyde and custers effect in the yeast Antonie Van Leeuwenhoek. 1981;47(3):209-15. doi: 10.1007/BF00403392.
5 Characterization of Thermotoga neapolitana Alcohol Dehydrogenases in the Ethanol Fermentation Pathway. Biology (Basel). 2022 Sep 5;11(9):1318. doi: 10.3390/biology11091318.
6 LABEL:ACTULOSE- lactulose solution
7 Ethanol Metabolism in the Liver, the Induction of Oxidant Stress, and the Antioxidant Defense System
8 Effects of increased transaldolase activity on D-xylulose and D-glucose metabolism in Saccharomyces cerevisiae cell extracts
9 Disposition, pharmacokinetics, and metabolism of 14C-fotemustine in cancer patients
10 [The metabolism of alcohol] Rev Med Liege. 2019 May;74(5-6):265-267.
11 ALDH1A3 Coordinates Metabolism With Gene Regulation in Pulmonary Arterial Hypertension. Circulation. 2021 May 25;143(21):2074-2090. doi: 10.1161/CIRCULATIONAHA.120.048845.

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