Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0285)
Drug Name
Cefaloridine
Synonyms
Cefaloridin; Cefaloridina; Cefaloridina [INN-Spanish]; Cefaloridinum; Cefaloridinum [INN-Latin]; Cefalorizin; Ceflorin; Cepaloridin; Cepalorin; Cephalomycine; Cephaloridin; Cephaloridinum; Ceporan; Ceporin; Ceporine; Cilifor; Deflorin; Ampligram; Betaine cephaloridine; Faredina; Glaxoridin; Intrasporin; Keflodin; Keflordin; Kefloridin; Kefspor; Lloncefal; Loridine; Sasperin; Sefacin; Verolgin; Vioviantine; cefaloridine; cephaloridine; 50-59-9; CHEBI:3537; N-(7-(2'-Thienylacetamidoceph-3-ylmethyl))-pyridinium-2-carboxylate; UNII-LVZ1VC61HB
Indication Staphylococcus infection [ICD11: 1B73] Phase 4 [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 415.5 Topological Polar Surface Area 147
Heavy Atom Count 28 Rotatable Bond Count 5
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 6
Cross-matching ID
PubChem CID
5773
ChEBI ID
CHEBI:3537
CAS Number
50-59-9
TTD Drug ID
D0F8IO
Formula
C19H17N3O4S2
Canonical SMILES
C1C(=C(N2C(S1)C(C2=O)NC(=O)CC3=CC=CS3)C(=O)[O-])C[N+]4=CC=CC=C4
InChI
1S/C19H17N3O4S2/c23-14(9-13-5-4-8-27-13)20-15-17(24)22-16(19(25)26)12(11-28-18(15)22)10-21-6-2-1-3-7-21/h1-8,15,18H,9-11H2,(H-,20,23,25,26)/t15-,18-/m1/s1
InChIKey
CZTQZXZIADLWOZ-CRAIPNDOSA-N
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Beta-lactamase (blaB) DME1026 Bacteroides uniformis
BLAC_BACUN
3.5.2.6
[2]
Beta-lactamase (blaB) DME2100 Burkholderia multivorans
PENA_BURM1
3.5.2.6
[3]
Cytochrome P450 2C8 (CYP2C8) DME0018 Homo sapiens
CP2C8_HUMAN
1.14.14.1
[4]
Experimental Enzyme Kinetic Data of This Drug
DME Name DME Info Kinetic Data Uniprot ID REF
Beta-lactamase (blaB) DME1026 Km = 177 microM
BLAC_BACUN
[2]
References
1 National Center for Advancing Translational Science-Inxight: drug (LVZ1VC61HB)
2 Purification and characterization of a new beta-lactamase from Bacteroides uniformis. Antimicrob Agents Chemother. 1995 Jul;39(7):1458-61.
3 Characterization of the penA and penR genes of Burkholderia cepacia 249 which encode the chromosomal class A penicillinase and its LysR-type transcriptional regulator. Antimicrob Agents Chemother. 1997 Nov;41(11):2399-405.
4 Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil. J Pharmacol Exp Ther. 2004 Oct;311(1):228-36.

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