Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0326)
Drug Name	Cinacalcet hydrochloride
Synonyms	Cinacalcet (hydrochloride); Cinacalcet HCl; Cinacalcet hydrochloride; Cinacalcet hydrochloride [USAN]; Cinacalcet; Cinacalcet (USAN); N-((1R)-1-(1-Naphthyl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine; N-((1R)-1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine; N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine; N-[(1R)-1-naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine; NCGC00181002-01; UAZ6V7728S; UNII-UAZ6V7728S; (R)-N-(1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine; 226256-56-0; AMG-073; AMG073; CHEBI:48390; DSSTox_CID_26792; DSSTox_RID_81909; Mimpara; Regpara; Sensipar; UNII-1K860WSG25; [(1R)-1-(naphthalen-1-yl)ethyl]({3-[3-(trifluoromethyl)phenyl]propyl})amine hydrochloride; (R)-N-(1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine hydrochloride; 1K860WSG25; 364782-34-3; AMG 073; AMG-073 HCL; AMG-073 HCl (Cinacalcet hydrochloride); AMG073 HCl; CHEBI:48391
Indication	Hyperparathyroidism [ICD11: 5A51]			Approved	[1]
Structure
Structure	3D MOL is unavailable		2D MOL
Pharmaceutical Properties	Molecular Weight	393.9	Topological Polar Surface Area		12
	Heavy Atom Count	27	Rotatable Bond Count		6
	Hydrogen Bond Donor Count	2	Hydrogen Bond Acceptor Count		4
Cross-matching ID	PubChem CID 156418 ChEBI ID CHEBI:48391 CAS Number 364782-34-3 TTD Drug ID D03YGR Formula C22H23ClF3N Canonical SMILES CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F.Cl InChI 1S/C22H22F3N.ClH/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25;/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3;1H/t16-;/m1./s1 InChIKey QANQWUQOEJZMLL-PKLMIRHRSA-N

The Metabolic Roadmap of This Drug

The Full List of Drug Metabolites (DM) of This Drug

DM Name	DM ID	PubChem ID	Reaction	DM Level	REF
Cinacalcet hydrochloride Metabolite M2a-Glu	DM018083	N. A.	Multi-steps Reaction - Oxidation; glucoronidation	1	[4]
Cinacalcet hydrochloride Metabolite M2b-Glu	DM018084	N. A.	Unclear - Unclear	1	[4]
Cinacalcet hydrochloride Metabolite M4	DM015962	19797640	Unclear - Unclear	1	[4]
Cinacalcet hydrochloride Metabolite M5	DM015376	2777683	Oxidation - Oxidation	1	[4]
Cinacalcet hydrochloride Metabolite M6	DM016234	62394948	Unclear - Unclear	2	[4]
Cinacalcet hydrochloride Metabolite M7	DM015342	719451	Unclear - Unclear	3	[4]
M-trifluoromethyl-benzoic acid	DM006588	9963	Unclear - Unclear	3	[4]
Cinacalcet hydrochloride Metabolite M7-Gly	DM015479	5889983	Unclear - Unclear	4	[4]
M-trifluoromethylhippuric acid	DM006589	2777432	Unclear - Unclear	4	[4]

The Full List of Metabolic Reaction (MR) of This Drug

MR ID	Reactant	Product	MR Type	DME	REF
MR009927	Cinacalcet hydrochloride	Cinacalcet hydrochloride Metabolite M5	Oxidation - Oxidation	Unclear	[4]
MR009933	Cinacalcet hydrochloride	Cinacalcet hydrochloride Metabolite M4	Unclear - Unclear	Unclear	[4]
MR009934	Cinacalcet hydrochloride	Cinacalcet hydrochloride Metabolite M2a-Glu	Multi-steps Reaction - Oxidation; glucoronidation	Unclear	[4]
MR009935	Cinacalcet hydrochloride	Cinacalcet hydrochloride Metabolite M2b-Glu	Unclear - Unclear	Unclear	[4]
MR009928	Cinacalcet hydrochloride Metabolite M5	Cinacalcet hydrochloride Metabolite M6	Unclear - Unclear	Unclear	[4]
MR009929	Cinacalcet hydrochloride Metabolite M6	Cinacalcet hydrochloride Metabolite M8	Unclear - Unclear	Unclear	[4]
MR009931	Cinacalcet hydrochloride Metabolite M6	Cinacalcet hydrochloride Metabolite M7	Unclear - Unclear	Unclear	[4]
MR009932	Cinacalcet hydrochloride Metabolite M7	Cinacalcet hydrochloride Metabolite M7-Gly	Unclear - Unclear	Unclear	[4]
MR009930	Cinacalcet hydrochloride Metabolite M8	Cinacalcet hydrochloride Metabolite M8-Gly	Unclear - Unclear	Unclear	[4]


⏷ Show the Full List of 9 MR(s)

Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug

DME Name	DME Info	Species	Uniprot ID	EC Number	REF
Cytochrome P450 1A2 (CYP1A2)	DME0003	Homo sapiens	CP1A2_HUMAN	1.14.14.1	[2]
Cytochrome P450 2D6 (CYP2D6)	DME0009	Homo sapiens	CP2D6_HUMAN	1.14.14.1	[3]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Homo sapiens	CP3A4_HUMAN	1.14.14.55	[3]

References
1	Cinacalcet Hydrochloride was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2	Effects of CYP3A inhibition on the metabolism of cilostazol. Clin Pharmacokinet. 1999;37 Suppl 2:61-8.
3	Clinical pharmacokinetic and pharmacodynamic profile of cinacalcet hydrochloride. Clin Pharmacokinet. 2009;48(5):303-11.
4	Cinacalcet Hydrochloride

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