Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0685)
Drug Name
Felodipine
Synonyms
Feloday; Felodipina; Felodipina [INN-Spanish]; Felodipine (Plendil); Felodipine [USAN:BAN:INN]; Felodipinum; Felodipinum [INN-Latin]; Felodur ER; Felogard; Flodil; Munobal; Munobal Retard; Penedil; Perfudal; Plandil; Plendil; Plendil Depottab; AGON SR; Plendil ER; Plendil Retard; Preslow; Prevex; Renedil; Splendil; dl-Felodipine; felodipine; 3-ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; 72509-76-3; 86189-69-7; Agon; BRN 4331472; C18H19Cl2NO4; CGH-869; H 154/82; H-154/82; Hydac; MLS000069629; Modip
Indication Essential hypertension [ICD11: BA00] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 384.2 Topological Polar Surface Area 64.599
Heavy Atom Count 25 Rotatable Bond Count 6
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 5
Cross-matching ID
PubChem CID
3333
PubChem SID
856004 ; 5309057 ; 7847385 ; 7979219 ; 8152117 ; 10321744 ; 11466506 ; 11467626 ; 11486291 ; 11528719 ; 12012613 ; 14927301 ; 16960569 ; 17405071 ; 24278449 ; 29222468 ; 46506968 ; 47509540 ; 47656605 ; 47879634 ; 48179244 ; 48328566 ; 48416001 ; 49698512 ; 50106289 ; 50106290 ; 53777614 ; 53788382 ; 56423042 ; 56424130 ; 56463217 ; 56463516 ; 57321731 ; 78292296 ; 85231057 ; 85788575 ; 87351806 ; 90340828 ; 92125582 ; 92303867 ; 92308861 ; 92711325 ; 93166891 ; 99453448 ; 103024636 ; 103543150 ; 103856247 ; 103914230 ; 104170219 ; 104253409
ChEBI ID
CHEBI:585948
CAS Number
72509-76-3
TTD Drug ID
D0WN0U
Formula
C18H19Cl2NO4
Canonical SMILES
CCOC(=O)C1=C(NC(=C(C1C2=C(C(=CC=C2)Cl)Cl)C(=O)OC)C)C
InChI
1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
InChIKey
RZTAMFZIAATZDJ-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Dehydrofelodipine DM000162
62970
Oxidation - Oxidation 1 [4]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR002850 Felodipine Dehydrofelodipine Oxidation - Oxidation CYP3A4 [4]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 3A4 (CYP3A4) DME0001 Homo sapiens
CP3A4_HUMAN
1.14.14.55
[2]
Cytochrome P450 3A5 (CYP3A5) DME0012 Homo sapiens
CP3A5_HUMAN
1.14.14.1
[3]
References
1 Felodipine was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Drug interactions with calcium channel blockers: possible involvement of metabolite-intermediate complexation with CYP3A. Drug Metab Dispos. 2000 Feb;28(2):125-30.
3 Drug Interactions Flockhart Table
4 A Physiologically Based Pharmacokinetic and Pharmacodynamic Model of the CYP3A4 Substrate Felodipine for Drug-Drug Interaction Modeling Pharmaceutics. 2022 Jul 15;14(7):1474. doi: 10.3390/pharmaceutics14071474.

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