Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0978)
Drug Name
Lorazepam
Synonyms
Larpose; Laubeel; Lorabenz; Lorapam; Lorazene; Lorazep; Lorazepam Intensol; Lorazin; Lorenin; Loridem; Lorsedal; Lozepam; Merlit; Norlormetazepam; Novhepar; Orfidal; Punktyl; Renaquil; Rocosgen; Sedatival; Sedizepan; Sidenar; Silence; Sinestron; Almazine; Anxiedin; Anzepam; Aplacasse; Aplacassee; Apo-Lorazepam; Ativan; Azurogen; Bonatranquan; Delormetazepam; Duralozam; Efasedan; Emotival; Equitam; Idalprem; Kalmalin; Stapam; Temesta; Tranqipam; Trapax; lorazepam; o-Chlorooxazepam; o-Chloroxazepam; 846-49-1; Donix; Lorax; Loraz; Quait; Tavor; Tolid; Wypax
Indication Anxiety disorder [ICD11: 6B00] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 321.2 Topological Polar Surface Area 61.7
Heavy Atom Count 21 Rotatable Bond Count 1
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
Cross-matching ID
PubChem CID
3958
PubChem SID
145006 ; 597377 ; 3249123 ; 4964189 ; 7847431 ; 7849642 ; 7979801 ; 8150120 ; 8152485 ; 10536882 ; 11336140 ; 11361379 ; 11462351 ; 14801418 ; 24896291 ; 29215381 ; 29223072 ; 46386878 ; 46508468 ; 48035217 ; 48416184 ; 49884087 ; 50340424 ; 53789194 ; 56313651 ; 57322068 ; 92308613 ; 99233258 ; 99302053 ; 103179427 ; 104134178 ; 104305018 ; 124659146 ; 124759848 ; 125536697 ; 126674761 ; 127741279 ; 131327750 ; 134337551 ; 134979720 ; 135697881 ; 137008105 ; 137201885 ; 140053026 ; 144097671 ; 144205222 ; 152043722 ; 160963534 ; 162022367 ; 162725399
ChEBI ID
ChEBI:52993
CAS Number
846-49-1
TTD Drug ID
D0E0OG
Formula
C15H10Cl2N2O2
Canonical SMILES
C1=CC=C(C(=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)O)Cl
InChI
1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)
InChIKey
DIWRORZWFLOCLC-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Lorazepam glucuronide DM006426
62966
Conjugation - Glucuronidation 1 [2] , [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR006905 Lorazepam Lorazepam glucuronide Conjugation - Glucuronidation UGT2B7 ... [2], [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
UDP-glucuronosyltransferase 2B15 (UGT2B15) DME0049 Homo sapiens
UDB15_HUMAN
2.4.1.17
[2]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME0040 Homo sapiens
UD2B7_HUMAN
2.4.1.17
[3]
References
1 Lorazepam was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Effect of the UGT2B15 genotype on the pharmacokinetics, pharmacodynamics, and drug interactions of intravenous lorazepam in healthy volunteers. Clin Pharmacol Ther. 2005 Jun;77(6):486-94.
3 Pharmacokinetic and pharmacodynamic interaction of lorazepam and valproic acid in relation to UGT2B7 genetic polymorphism in healthy subjects. Clin Pharmacol Ther. 2008 Apr;83(4):595-600.

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