Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR1101)
Drug Name
Glinsuna
Synonyms
Glinsuna; Glufast; Glufast (TN); KAD-1229 Calcium Hydrate; Mitiglinide calcium dihydrate; Mitiglinide calcium hydrate; S-21403 calcium hydrate; Tox21_112571; (S)-2-Benzyl-4-oxo-4-(cis-perhydroisoindol-2-yl)butyric acid calcium salt dihydrate; 9651C21W3Z; AC1OCF6X; AKOS015855296; CHEMBL1603301; DSSTox_CID_26728; DSSTox_GSID_46728; DSSTox_RID_81858; DTXSID5046728; Mitiglinide calcium hydrate (JP17); NCGC00167578-01; UNII-9651C21W3Z
Indication Diabetes mellitus [ICD11: 5A10] Phase 3 [1]
Structure
3D MOL is unavailable 2D MOL
Pharmaceutical Properties Molecular Weight 704.9 Topological Polar Surface Area 123
Heavy Atom Count 49 Rotatable Bond Count 8
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 8
Cross-matching ID
PubChem CID
6918235
CAS Number
207844-01-7
TTD Drug ID
D0P2YU
Formula
C38H52CaN2O8
Canonical SMILES
C1CCC2CN(CC2C1)C(=O)CC(CC3=CC=CC=C3)C(=O)[O-].C1CCC2CN(CC2C1)C(=O)CC(CC3=CC=CC=C3)C(=O)[O-].O.O.[Ca+2]
InChI
1S/2C19H25NO3.Ca.2H2O/c2*21-18(20-12-15-8-4-5-9-16(15)13-20)11-17(19(22)23)10-14-6-2-1-3-7-14;;;/h2*1-3,6-7,15-17H,4-5,8-13H2,(H,22,23);;2*1H2/q;;+2;;/p-2/t2*15-,16+,17-;;;/m00.../s1
InChIKey
QEVLNUAVAONTEW-UZYHXJQGSA-L
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Glinsuna Metabolite M1 DM004174 N. A. Conjugation - Glucuronidation 1 [2] , [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR012935 Glinsuna Glinsuna Metabolite M1 Conjugation - Glucuronidation UGT1A3 ... [2], [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME0041 Homo sapiens
UD13_HUMAN
2.4.1.17
[2]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME0041 Homo sapiens
UD13_HUMAN
2.4.1.17
[2] , [3]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME0040 Homo sapiens
UD2B7_HUMAN
2.4.1.17
[2] , [3]
UDP-glucuronosyltransferase 3A2 (UGT3A2) DMEN401 Homo sapiens
UD3A2_HUMAN
2.4.1.17
[2] , [3]
References
1 ClinicalTrials.gov (NCT01456130) Long-term Study of Alogliptin as an Add-on to Rapid-Acting Insulin Secretagogues in Type 2 Diabetes.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
3 Carboxyl-glucuronidation of mitiglinide by human UDP-glucuronosyltransferases. Biochem Pharmacol. 2007 Jun 1;73(11):1842-51.

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