Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR1120)
Drug Name
N,N-dimethylformamide
Synonyms
DMF (amide); Dimethyl formamide; Dimethylamid kyseliny mravenci; Dimethylforamide; Dimethylformamid; Dimethylformamid [German]; Dimethylformamide; Dimetilformamide; Dimetilformamide [Italian]; Dimetylformamidu; Dimetylformamidu [Czech]; Dwumetyloformamid; Dwumetyloformamid [Polish]; Formamide, N,N-dimethyl-; Formyldimethylamine; N,N-DIMETHYLFORMAMIDE; N,N-Dimethyl formamide; N,N-Dimethylformamid; N,N-Dimethylmethanamide; N-Formyldimethylamine; n,n,dimethylformamide; Caswell No. 366A; DMF; DMFA; NCI-C60913
Indication Discovery agent Investigative [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 73.09 Topological Polar Surface Area 20.3
Heavy Atom Count 5 Rotatable Bond Count 0
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 1
Cross-matching ID
PubChem CID
6228
PubChem SID
6023 ; 71484 ; 588252 ; 596556 ; 3133020 ; 5056504 ; 7887090 ; 8144024 ; 8153911 ; 10532602 ; 11110291 ; 12055888 ; 15218622 ; 17388882 ; 17389908 ; 24849438 ; 24849479 ; 24853607 ; 24856379 ; 24859200 ; 24859940 ; 24865091 ; 24867382 ; 24867912 ; 24872907 ; 24883591 ; 24886401 ; 24893883 ; 26719250 ; 26752801 ; 29225225 ; 37395225 ; 39218025 ; 41146321 ; 46506036 ; 48413664 ; 48416762 ; 48421486 ; 48423335 ; 48425349 ; 48425350 ; 49855709 ; 52530036 ; 53788473 ; 56312817 ; 56313658 ; 57288677 ; 57323275 ; 57390177 ; 57647430
ChEBI ID
CHEBI:17741
CAS Number
68-12-2
TTD Drug ID
D0E1KX
Formula
C3H7NO
Canonical SMILES
CN(C)C=O
InChI
1S/C3H7NO/c1-4(2)3-5/h3H,1-2H3
InChIKey
ZMXDDKWLCZADIW-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Dimethylamine DM003932
674
Unclear 1 [3]
Formic acid DM000198
284
Unclear 1 [3]
N-methyl-N-(hydroxymethyl)formamide DM003927 N. A. Unclear 1 [4]
N-methylformamide (MF) DM003928
31254
Unclear 1 [5]
AMCC DM003931
108218
Unclear 2 [6]
N-methylformamide (MF) DM003928
31254
Unclear 2 [4]
NMF-OH DM003929 N. A. Unclear 2 [6]
AMCC DM003931
108218
Unclear 3 [6]
N,N-dimethylformamide F DM003930 N. A. Unclear 3 [6]
NMF-OH DM003929 N. A. Unclear 3 [6]
N,N-dimethylformamide F DM003930 N. A. Unclear 4 [6]
⏷ Show the Full List of 11  DM(s)
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR004288 N,N-dimethylformamide N-methyl-N-(hydroxymethyl)formamide Unclear Unclear [4]
MR004293 N,N-dimethylformamide N-methylformamide (MF) Unclear Unclear [5]
MR004295 N,N-dimethylformamide Dimethylamine Unclear Unclear [3]
MR004296 N,N-dimethylformamide Formic acid Unclear Unclear [3]
MR004289 N-methyl-N-(hydroxymethyl)formamide N-methylformamide (MF) Unclear Unclear [4]
MR004294 N-methyl-N-(hydroxymethyl)formamide AMCC Unclear Unclear [6]
MR014108 N-methylformamide (MF) AMCC Unclear Unclear [6]
MR014109 N-methylformamide (MF) NMF-OH Unclear Unclear [6]
MR004290 N-methylformamide (MF) NMF-OH Unclear Unclear [6]
MR004292 N-methylformamide (MF) AMCC Unclear Unclear [6]
MR014110 NMF-OH N,N-dimethylformamide F Unclear Unclear [6]
MR004291 NMF-OH N,N-dimethylformamide F Unclear Unclear [6]
⏷ Show the Full List of 12 MR(s)
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 2E1 (CYP2E1) DME0013 Homo sapiens
CP2E1_HUMAN
1.14.14.1
[2]
References
1 Liver disease associated with occupational exposure to the solvent dimethylformamide. Ann Intern Med. 1988 May;108(5):680-6.
2 Association between CYP2E1 and GOT2 gene polymorphisms and susceptibility and low-dose N,N-dimethylformamide occupational exposure-induced liver injury. Int Arch Occup Environ Health. 2019 Oct;92(7):967-975.
3 Anaerobic treatment of N, N-dimethylformamide-containing wastewater by co-culturing two sources of inoculum
4 High-performance liquid chromatographic determination of N-methylformamide and N-methyl-N-(hydroxymethyl)-formamide in human urine
5 [The toxicity of N,N-dimethylformamide (DMF)]
6 Simultaneous determination of N-hydroxymethyl-N-methylformamide, N-methylformamide and N-acetyl-S-(N-methylcarbamoyl)cystein in urine samples from workers exposed to N,N-dimethylformamide by liquid chromatography-tandem mass spectrometry

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