Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2025)
Drug Name
Glycine
Synonyms
Glicina [INN-Spanish]; Glicoamin; Glycine [INN]; Glycine, non-medical; Glycinum; Glycinum [INN-Latin]; Glycocoll; Glycolixir; Glycosthene; Glykokoll; Glyzin; Gyn-hydralin; H-Gly-OH; Hampshire glycine; L-Glycine; Leimzucker; Acide aminoacetique [INN-French]; Acido aminoacetico [INN-Spanish]; Acidum aminoaceticum [INN-Latin]; Aciport; Aminoazijnzuur; Aminoethanoic acid; Amitone; Corilin; GLY (IUPAC abbrev); Sucre de gelatine; aminoacetic acid; glycine; 2-Aminoacetic acid; 56-40-6; Acetic acid, amino-; CCRIS 5915; FEMA No. 3287; Padil; gly
Indication Vitamin deficiency [ICD11: 5B55] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 75.07 Topological Polar Surface Area 63.3
Heavy Atom Count 5 Rotatable Bond Count 1
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
Cross-matching ID
PubChem CID
750
PubChem SID
3339 ; 86929 ; 585843 ; 589752 ; 626974 ; 827140 ; 829229 ; 829387 ; 830123 ; 833865 ; 836630 ; 836631 ; 838484 ; 841093 ; 3133349 ; 6435754 ; 7346033 ; 7847079 ; 7887927 ; 7979426 ; 8026292 ; 8026825 ; 8138085 ; 8145759 ; 8150769 ; 10527483 ; 11113413 ; 11528254 ; 14747327 ; 16955354 ; 17404564 ; 24439112 ; 24775647 ; 24849510 ; 24860042 ; 24865701 ; 24873323 ; 24895210 ; 24895217 ; 24895290 ; 24895306 ; 24895353 ; 24895355 ; 24898980 ; 24901611 ; 26718882 ; 26751653 ; 33728423 ; 37415007 ; 46295148
ChEBI ID
ChEBI:15428
CAS Number
56-40-6
TTD Drug ID
D0M8AB
Formula
C2H5NO2
Canonical SMILES
C(C(=O)O)N
InChI
1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChIKey
DHMQDGOQFOQNFH-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Methylamine DM003096
6329
Oxidation - Oxidative Decarboxylation 1 [5]
Serine DM002140
5951
Unclear 1 [6]
Dihydrolipoamide DM002138
663
Unclear 2 [2]
Lipoic acid DM002139
6112
Unclear 3 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR002922 Glycine Serine Unclear Unclear [6]
MR002923 Glycine Methylamine Oxidation - Oxidative Decarboxylation GCSH [5]
MR002920 Methylamine Dihydrolipoamide Unclear GCSH ... [2]
MR002921 Dihydrolipoamide Lipoic acid Unclear GCSH ... [2]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Aminomethyltransferase (AMT) DMEN051 Homo sapiens
GCST_HUMAN
1.14.17.1
[2]
Bile acid-CoA thioesterase (BAAT) DME0200 Homo sapiens
BAAT_HUMAN
2.3.1.65
[3]
Delta-aminolevulinate synthase 2 (ALAS2) DME0487 Homo sapiens
HEM0_HUMAN
2.3.1.37
[4]
Dihydrolipoyl dehydrogenase (DLD) DMEN052 Homo sapiens
DLDH_HUMAN
2.3.1.57
[2]
Glycine cleavage system H protein, mitochondrial (GCSH) DMEN050 Homo sapiens
GCSH_HUMAN
Not Available [5]
Experimental Enzyme Kinetic Data of This Drug
DME Name DME Info Kinetic Data Uniprot ID REF
Delta-aminolevulinate synthase 2 (ALAS2) DME0487 Km = 12 microM
HEM0_HUMAN
[4]
Bile acid-CoA thioesterase (BAAT) DME0200 Km = 5 microM
BAAT_HUMAN
[3]
References
1 Glycine was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 DrugBank(Pharmacology-Metabolism)Glycine
3 Bile acid coenzyme A: amino acid N-acyltransferase in the amino acid conjugation of bile acids. Methods Enzymol. 2005;400:374-94.
4 Molecular expression and characterization of erythroid-specific 5-aminolevulinate synthase gain-of-function mutations causing X-linked protoporphyria. Mol Med. 2013 Mar 5;19:18-25.
5 Glycine metabolism in animals and humans: implications for nutrition and health Amino Acids. 2013 Sep;45(3):463-77. doi: 10.1007/s00726-013-1493-1.
6 Pharmacokinetics and cerebral distribution of glycine administered to rats Amino Acids. 2012 Jun;42(6):2129-37. doi: 10.1007/s00726-011-0950-y.

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