Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN051)
DME Name Aminomethyltransferase (AMT), Homo sapiens
Gene Name AMT
UniProt ID
GCST_HUMAN
EC Number    EC: 1.14.17.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor
EC: 1.14.17.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MQRAVSVVARLGFRLQAFPPALCRPLSCAQEVLRRTPLYDFHLAHGGKMVAFAGWSLPVQ
YRDSHTDSHLHTRQHCSLFDVSHMLQTKILGSDRVKLMESLVVGDIAELRPNQGTLSLFT
NEAGGILDDLIVTNTSEGHLYVVSNAGCWEKDLALMQDKVRELQNQGRDVGLEVLDNALL
ALQGPTAAQVLQAGVADDLRKLPFMTSAVMEVFGVSGCRVTRCGYTGEDGVEISVPVAGA
VHLATAILKNPEVKLAGLAARDSLRLEAGLCLYGNDIDEHTTPVEGSLSWTLGKRRRAAM
DFPGAKVIVPQLKGRVQRRRVGLMCEGAPMRAHSPILNMEGTKIGTVTSGCPSPSLKKNV
AMGYVPCEYSRPGTMLLVEVRRKQQMAVVSKMPFVPTNYYTLK
Structure
1WSR ; 1WSV ;
Function The glycine cleavage system catalyzes the degradation of glycine.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Glycine
 Drug Info Approved Vitamin deficiency ICD11: 5B55 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
L-histidine
 Drug Info Investigative Discovery agent ICD: N.A. [2]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR002920 Methylamine Dihydrolipoamide Unclear - Unclear Glycine [1]
References
1 DrugBank(Pharmacology-Metabolism)Glycine
2 Histidine in Health and Disease: Metabolism, Physiological Importance, and Use as a Supplement

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.