Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2083)
Drug Name
D-glucose 6-phosphate
Synonyms
Aldohexose 6-phosphate; D(+)-Glucopyranose 6-phosphate; D-Glucose 6-phosphate; D-Glucose 6-phosphoric acid; D-glucose-6-phosphate; SCHEMBL6599; VFRROHXSMXFLSN-SLPGGIOYSA-N; ZINC19850142; glucose-6 phosphate; (2R,3R,4S,5R)-2,3,4,5-tetrahydroxy-6-oxohexyl dihydrogen phosphate; 375AW34SQA; 56-73-5; 6-O-phosphono-D-glucose; AC1L98E0; CHEBI:15954; CTK3I9725; UNII-375AW34SQA; [(2R,3R,4S,5R)-2,3,4,5-tetrahydroxy-6-oxohexyl] dihydrogen phosphate; aldehydo-D-glucose 6-(dihydrogen phosphate); aldehydo-D-glucose 6-phosphate
Indication Discovery agent Investigative [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 260.14 Topological Polar Surface Area 165
Heavy Atom Count 16 Rotatable Bond Count 7
Hydrogen Bond Donor Count 6 Hydrogen Bond Acceptor Count 9
Cross-matching ID
PubChem CID
439958
ChEBI ID
CHEBI:15954
CAS Number
56-73-5
Formula
C6H13O9P
Canonical SMILES
C(C(C(C(C(C=O)O)O)O)O)OP(=O)(O)O
InChI
1S/C6H13O9P/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14/h1,3-6,8-11H,2H2,(H2,12,13,14)/t3-,4+,5+,6+/m0/s1
InChIKey
VFRROHXSMXFLSN-SLPGGIOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Glucose-1-phosphate DM004098
65533
Unclear 1 [3]
UDP-glc DM004097
8629
Unclear 2 [3]
Glucogen DM005865 N. A. Unclear 3 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR006279 D-glucose 6-phosphate Glucose-1-phosphate Unclear PGM2 [3]
MR006280 D-glucose 1-phosphate UDP-glc Unclear Unclear [3]
MR006281 UDP-glc Glucogen Unclear Unclear [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Glucose-6-phosphatase beta (G6PC3) DME0523 Homo sapiens
G6PC3_HUMAN
3.1.3.9
[2]
Phosphoglucomutase 2 (PGM2) DMEN317 Saccharomyces cerevisiae
PGM2_YEAST
5.4.2.2
[3]
Experimental Enzyme Kinetic Data of This Drug
DME Name DME Info Kinetic Data Uniprot ID REF
Glucose-6-phosphatase beta (G6PC3) DME0523 Km = 1 microM
G6PC3_HUMAN
[2]
References
1 Role of 2-deoxy-D-glucose in the inhibition of phagocytosis by mouse peritoneal macrophage. Biochim Biophys Acta. 1985 May 30;845(2):204-15.
2 Identification and characterisation of a new human glucose-6-phosphatase isoform. FEBS Lett. 2003 Sep 11;551(1-3):159-64.
3 Intracellular glucose 1-phosphate and glucose 6-phosphate levels modulate Ca2+ homeostasis in Saccharomyces cerevisiae

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