Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2145)
Drug Name
Fructose 6-phosphate
Synonyms
D-Fructose 6-phosphorate; D-fructose-6-P; D-fructose-6-phosphate; D-fructose-6P; FRUCTOSE -6-PHOSPHATE; Fructose 6-(dihydrogen phosphate); Fructose 6-Phosphate; Fructose 6-phosphoric acid; SCHEMBL8230; ZINC85994845; d-fructose-6-phosphate (open form); fru-6-P; fructose-6-P; fructose-6P; keto-D-fructose 6-phosphate; 2012QM764Y; 6-O-phosphono-D-fructose; 6814-87-5; AC1L2C15; AC1Q28E6; AJ-127870; CHEBI:15946; CTK5C7413; DB04493; EINECS 211-395-6; F6R; Fructose, 6-(dihydrogen phosphate); GSXOAOHZAIYLCY-HSUXUTPPSA-N; UNII-2012QM764Y
Indication Discovery agent Investigative [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 260.14 Topological Polar Surface Area 165
Heavy Atom Count 16 Rotatable Bond Count 7
Hydrogen Bond Donor Count 6 Hydrogen Bond Acceptor Count 9
Cross-matching ID
PubChem CID
69507
PubChem SID
841537 ; 855114 ; 7887397 ; 7887546 ; 8145072 ; 8192994 ; 26737151 ; 43125971 ; 55161557 ; 56401857 ; 57317420 ; 75723126 ; 92297569 ; 103823557 ; 104345110 ; 117392205 ; 125001819 ; 125333318 ; 126523022 ; 127335746 ; 127335747 ; 127335748 ; 127335749 ; 135026903 ; 135072635 ; 135653532 ; 137105997 ; 144223749 ; 162162882 ; 162895730 ; 163686520 ; 196679219 ; 198954512 ; 223637041 ; 223738639 ; 226399475 ; 249541529 ; 252400783
ChEBI ID
CHEBI:15946
CAS Number
643-13-0
TTD Drug ID
D0H3IJ
Formula
C6H13O9P
Canonical SMILES
C(C(C(C(C(=O)CO)O)O)O)OP(=O)(O)O
InChI
1S/C6H13O9P/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14/h4-7,9-11H,1-2H2,(H2,12,13,14)/t4-,5-,6-/m1/s1
InChIKey
GSXOAOHZAIYLCY-HSUXUTPPSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Fructose 1, 6-bisphosphate DM005892
5460765
Unclear 1 [4]
Fructose 1, 6-bisphosphate DM005892
5460765
Unclear 1 [5]
Fructose 2, 6-bisphosphate DM005893
105021
Unclear 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR006319 Fructose 6-phosphate Fructose 1, 6-bisphosphate Unclear PFP1 [5]
MR006320 Fructose 6-phosphate Fructose 2, 6-bisphosphate Unclear F-6-P,2-kinase [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
ATP-dependent 6-phosphofructokinase (pfkA) DME1154 Lactobacillus delbrueckii
PFKA_LACDE
2.7.1.11
[2]
fructose-6-phosphate,2-kinase (F-6-P,2-kinase) DMEN296 Homo sapiens Not Available Not Available [3]
Phosphofructokinase-1 (PFK1) DMEN295 Bacteroides fragilis Not Available Not Available [4]
Pyrophosphate\fructose 6\phosphate 1\phosphotransferase (PFP1) DMEN294 . Not Available Not Available [5]
References
1 Inverse relationship between human erythrocyte fructose-6-phosphate and short-chain fatty acid levels. Med Hypotheses. 2018 Dec;121:164-166.
2 Purification and properties of the phosphofructokinase from Lactobacillus bulgaricus. A non-allosteric analog of the enzyme from Escherichia coli. Eur J Biochem. 1991 Jun 15;198(3):683-7.
3 Fructose-6-phosphate,2-kinase activity in human erythrocytes
4 Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations
5 Pyrophosphate-fructose 6-phosphate 1-phosphotransferase (PFP1) regulates starch biosynthesis and seed development via heterotetramer formation in rice (Oryza sativa L.)

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