Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2158)
Drug Name
Neomycin
Synonyms
Neobiotic; Neobrettin; Neolate; Neomas; Neomcin; Neomicina; Neomicina [DCIT]; Neomin; Neomycin; Neomycin B sulfate; Neomycin solution; Neomycine [INN-French]; Neomycinum; Neomycinum [INN-Latin]; Nivemycin; PIMAVECORT; Sofra-Tulle (TN); Soframycin; Soframycin (TN); Soframycin Ophthalmic; Soframycine; Tuttomycin; USAF CB-19; VONAMYCIN; Vonamycin powder V; neomycin; Actilin; Actiline; Antibiotic 10676; Antibiotique; BDG-(1-4)CYY-(5-1)RIB-(3-1)IDG; BDG-(1-4)NEB-(5-1)RIB-(3-1)NED; Endomixin; Enterfram; Fradiomycin; Fradiomycin B; Fradiomycinum; Framicetina; Framicetina [INN-Spanish]; Framycetin (INN); Framycetin [INN:BAN:DCF]; Framycetine; Framycetine [INN-French]; Framycetinum; Framycetinum [INN-Latin]; Framygen; Fraquinol; Myacine; Myacyne; Mycifradin; Myciguent; NEOMYCIN AND POLYMYXIN B SULFATES; NEOMYCIN B; NEOMYCIN SULFATE; Neo-Fradin; Neo-Rx; (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside; (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol; 119-04-0; Antibiotic produced by Streptomyces decaris Neomycin B; Caswell No 595; D-Streptamine, O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1->3)-O-beta-D-ribofuranosyl-(1->5)]-O-[2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl-(1->4)]-2-deoxy; NMY
Indication Hepatic encephalopathy [ICD11: DB99] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 614.6 Topological Polar Surface Area 353
Heavy Atom Count 42 Rotatable Bond Count 9
Hydrogen Bond Donor Count 13 Hydrogen Bond Acceptor Count 19
Cross-matching ID
PubChem CID
8378
PubChem SID
4872 ; 600744 ; 7886109 ; 7886110 ; 7889440 ; 8027095 ; 8155893 ; 11108087 ; 14789604 ; 16359677 ; 17398248 ; 24886366 ; 24897464 ; 26705169 ; 26713687 ; 26715354 ; 29227077 ; 46505525 ; 46508892 ; 47589231 ; 48185242 ; 48259497 ; 48416318 ; 48498331 ; 49699023 ; 49703385 ; 49997098 ; 49997102 ; 50124333 ; 53788467 ; 80496344 ; 85164700 ; 92308991 ; 104317690 ; 123097006 ; 124576752 ; 124766144 ; 126666617 ; 127317005 ; 127317006 ; 127317007 ; 127317008 ; 127317009 ; 127317010 ; 127317011 ; 127317012 ; 127317013 ; 127317014 ; 127317015 ; 127317016
ChEBI ID
ChEBI:7508
CAS Number
119-04-0
TTD Drug ID
D05JNI
Formula
C23H46N6O13
Canonical SMILES
C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N
InChI
1S/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1
InChIKey
PGBHMTALBVVCIT-VCIWKGPPSA-N
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Aminoglycoside N-acetyltransferase (aacC2) DME1172 Acinetobacter baumannii
AAC6_ACIBA
2.3.1.82
[2]
Aminoglycoside O-phosphotransferase (aphA6) DME1068 Acinetobacter baumannii
KKA6_ACIBA
2.7.1.95
[2]
References
1 Neomycin was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Relationship between antimicrobial resistance and aminoglycoside-modifying enzyme gene expressions in Acinetobacter baumannii. Chin Med J (Engl). 2005 Jan 20;118(2):141-5.

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