Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2259)
Drug Name
Amantadine
Synonyms
Adamantamine; Adamantan-1-amine; Adamantan-1-ylamine; Adamantanamine; Adamantylamine; Amantadina; Amantadina [INN-Spanish]; Amantadine (INN); Amantadine Base; Amantadine [INN:BAN]; Amantadinum; Amantadinum [INN-Latin]; Amantidine; Aminoadamantane; ADAMANTANE,1-AMINO; BIA4304; Endantadine; Gen-Amantadine; Mantadine; OR14310; Pk-merz; Symadine; Symmetrel (TN); TCMDC-125869; Tricyclo(3.3.1.13,7)decan-1-amine; Wiregyt; 1-Adamantamine; 1-Adamantanamine; 1-Adamantanamine (8CI); 1-Adamantylamine; 1-Aminoadamantane; 1-Aminotricyclo(3.3.1.1(sup 3,7))decane; Amant; Tricyclo(3.3.1.1(3,7))-decan-1-amine; Tricyclo(3.3.1.1(sup 3,7))decan-1-amine; Tricyclo(3.3.1.1(sup 3.7))decan-1-amine; Tricyclo[3.3.1.1(3,7)]decan-1-amine; Tricyclo[3.3.1.1(3,7)]decan-1-ylamine; Tricyclo[3.3.1.1(3,7)]decane-1-amine; Tricyclo[3.3.1.1(sup3,7)]decan-1-amine; Tricyclo[3.3.1.1^3,7]decan-1-amine; Tricyclo[3.3.1.1~3,7~]decan-1-amine
Indication Influenza virus infection [ICD11: 1E30] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 151.25 Topological Polar Surface Area 26
Heavy Atom Count 11 Rotatable Bond Count 0
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 1
Cross-matching ID
PubChem CID
2130
PubChem SID
9036 ; 461565 ; 588114 ; 597379 ; 3136147 ; 5106490 ; 7978680 ; 8147192 ; 8151445 ; 10535392 ; 11110715 ; 11335990 ; 11361229 ; 11362804 ; 11365366 ; 11367928 ; 11371422 ; 11373687 ; 11376090 ; 11448576 ; 11462201 ; 11466435 ; 11467555 ; 11483738 ; 11486009 ; 11487897 ; 11490107 ; 11491949 ; 11493844 ; 15170902 ; 15219251 ; 16666659 ; 24848359 ; 26755640 ; 26755641 ; 29221309 ; 30400536 ; 38395099 ; 46168239 ; 46507081 ; 47216816 ; 47216817 ; 47440544 ; 47515356 ; 47589230 ; 47736526 ; 47959791 ; 48035167 ; 48035168 ; 48259495
ChEBI ID
ChEBI:2618
CAS Number
768-94-5
TTD Drug ID
D02KRS
Formula
C10H17N
Canonical SMILES
C1C2CC3CC1CC(C2)(C3)N
InChI
1S/C10H17N/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H,1-6,11H2
InChIKey
DKNWSYNQZKUICI-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
1-Acetamidoadamantane DM000859
64153
Unclear 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR000164 Amantadine 1-Acetamidoadamantane Unclear Unclear [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Unclear metabolic mechanism (DME-unclear) DME1251 Bacteroides fragilis Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1254 Bacteroides thetaiotaomicron Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1256 Bacteroides sartorii Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1391 Bifidobacterium ruminatum Not Available Not Available [2]
References
1 Amantadine was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
3 LABEL:MANTADINE capsule

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