Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1254)
DME Name Unclear metabolic mechanism (DME-unclear), Bacteroides thetaiotaomicron
Gene Name DME-unclear
Lineage    Species: Bacteroides thetaiotaomicron     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides thetaiotaomicron
Subspecies: Bacteroides thetaiotaomicron 7330
Subspecies: Bacteroides thetaiotaomicron 3731
Subspecies: Bacteroides thetaiotaomicron VPI-5482
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:        65 Drugs
Galantamine hydrobromide
 Drug Info Approved Alzheimer disease ICD11: 8A20 [1]
Naloxone
 Drug Info Approved Opiate dependence ICD11: 6C43 [1]
Linagliptin
 Drug Info Approved Diabetes mellitus ICD11: 5A10 [1]
Irbesartan
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Mycophenolate mofetil
 Drug Info Approved Crohn disease ICD11: DD70 [1]
Tacrolimus
 Drug Info Approved Ulcerative colitis ICD11: DD71 [1]
Febuxostat
 Drug Info Approved Hyperuricaemia ICD11: 5C55 [1]
Deflazacort
 Drug Info Approved Muscular dystrophy ICD11: 8C70 [1]
Carvedilol
 Drug Info Approved Congestive heart failure ICD11: BD10 [1]
Digitoxin
 Drug Info Approved Congestive heart failure ICD11: BD10 [1]
Levonorgestrel
 Drug Info Approved Menorrhagia ICD11: GA20 [1]
Naproxen
 Drug Info Approved Rheumatoid arthritis ICD11: FA20 [1]
Nateglinide
 Drug Info Approved Diabetes mellitus ICD11: 5A10 [1]
Norethindrone acetate
 Drug Info Approved Menorrhagia ICD11: GA20 [1]
Repaglinide
 Drug Info Approved Diabetes mellitus ICD11: 5A10 [1]
Diltiazem hydrochloride
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Etodolac
 Drug Info Approved Rheumatoid arthritis ICD11: FA20 [1]
Fluoxetine hydrochloride
 Drug Info Approved Depression ICD11: 6A71 [1]
Indomethacin
 Drug Info Approved Rheumatoid arthritis ICD11: FA20 [1]
Isradipine
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Oxaprozin
 Drug Info Approved Rheumatoid arthritis ICD11: FA20 [1]
Riluzole
 Drug Info Approved Amyotrophic lateral sclerosis ICD11: 8B60 [1]
Sulfinpyrazone
 Drug Info Approved Uncontrolled gout ICD11: FA25 [1]
Betamethasone valerate
 Drug Info Approved Psoriasis vulgaris ICD11: EA90 [1]
Clonidine
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Danazol
 Drug Info Approved Endometriosis ICD11: GA10 [1]
Famciclovir
 Drug Info Approved Genital herpes ICD11: 1A94 [1]
Omeprazole
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Ritonavir
 Drug Info Approved Human immunodeficiency virus infection ICD11: 1C60 [1]
Sulfasalazine
 Drug Info Approved Rheumatoid arthritis ICD11: FA20 [1]
Tolazamide
 Drug Info Approved Diabetes mellitus ICD11: 5A10 [1]
Vilazodone hydrochloride
 Drug Info Approved Depression ICD11: 6A71 [1]
Clemastine fumarate
 Drug Info Approved Pulmonary oedema ICD11: CB01 [1]
Digoxin
 Drug Info Approved Cardiac arrhythmia ICD11: BC65 [1]
Ezetimibe
 Drug Info Approved Hypertriglyceridaemia ICD11: 5C80 [1]
Griseofulvin
 Drug Info Approved Dermatophytosis ICD11: 1F28 [1]
Lovastatin
 Drug Info Approved Hypertriglyceridaemia ICD11: 5C80 [2]
Nizatidine
 Drug Info Approved Peptic ulcer ICD11: DA61 [1]
Paclitaxel
 Drug Info Approved Ovarian cancer ICD11: 2C73 [1]
Pantoprazole sodium
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Procarbazine
 Drug Info Approved Anaplastic large cell lymphoma ICD11: 2A90 [1]
Sumatriptan succinate
 Drug Info Approved Migraine ICD11: 8A80 [1]
Voriconazole
 Drug Info Approved Candidiasis ICD11: 1F23 [1]
Bromocriptine mesylate
 Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Carisoprodol
 Drug Info Approved Depression ICD11: 6A71 [1]
Cimetidine
 Drug Info Approved Duodenal ulcer ICD11: DA63 [1]
Clopidogrel bisulfate
 Drug Info Approved Acute coronary syndrome ICD11: BA4Z [1]
Entacapone
 Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Ergotamine tartrate
 Drug Info Approved Migraine ICD11: 8A80 [1]
Fluconazole
 Drug Info Approved Candidiasis ICD11: 1F23 [1]
Mebendazole
 Drug Info Approved Ascariasis ICD11: 1F62 [1]
Megestrol acetate
 Drug Info Approved Breast cancer ICD11: 2C60 [1]
Melphalan
 Drug Info Approved Multiple myeloma ICD11: 2A83 [1]
Quinapril
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Tinidazole
 Drug Info Approved Protozoan infection ICD11: 1F5Z [1]
Amantadine
 Drug Info Approved Influenza virus infection ICD11: 1E30 [1]
Benazepril
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Tadalafil
 Drug Info Approved Erectile dysfunction ICD11: HA01 [1]
Telmisartan
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Valsartan
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Cetirizine
 Drug Info Approved Allergy ICD11: 4A80 [1]
Dexamethasone acetate
 Drug Info Approved Rheumatoid arthritis ICD11: FA20 [1]
Diflorasone diacetate
 Drug Info Approved Rosacea ICD11: ED90 [1]
Ramelteon
 Drug Info Approved Insomnia ICD11: 7A00 [1]
Sotalol
 Drug Info Approved Atrial fibrillation ICD11: BC81 [1]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:        12 Drugs
Cyproterone acetate
 Drug Info Phase 4 Polycystic ovary syndrome ICD11: 5A80 [1]
Famprofazone
 Drug Info Phase 4 Anaesthesia ICD11: 8E22 [1]
Artemisinin
 Drug Info Phase 4 Malaria ICD11: 1F40 [1]
Phenazopyridine
 Drug Info Phase 4 Infectious cystitis ICD11: GC00 [1]
Idebenone
 Drug Info Phase 4 Mitochondrial myopathy ICD11: 8C73 [1]
Tranilast
 Drug Info Phase 4 Conjunctivitis ICD11: 9A60 [1]
Gliclazide
 Drug Info Phase 4 Diabetes mellitus ICD11: 5A10 [1]
L-phenylalanine
 Drug Info Phase 4 Phenylketonuria ICD11: 5C50 [3]
Pericyazine
 Drug Info Phase 4 Anxiety disorder ICD11: 6B00 [1]
Racecadotril
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
Bisacodyl
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
Pidotimod
 Drug Info Phase 4 Pulmonary tuberculosis ICD11: 1B10 [1]
      Drugs in Phase 3 Clinical Trial Click to Show/Hide the Full List of Drugs:          2 Drugs
LS-187709
 Drug Info Phase 3 Psoriasis vulgaris ICD11: EA90 [1]
OPC-12759
 Drug Info Phase 3 Peptic ulcer ICD11: DA61 [1]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          4 Drugs
Roxatidine
 Drug Info Phase 2 Gastro-oesophageal reflux disease ICD11: DA22 [1]
W-108598
 Drug Info Phase 2 Myasthenia gravis ICD11: 8C60 [1]
TU-199
 Drug Info Phase 2 Gastro-oesophageal reflux disease ICD11: DA22 [1]
BRN-0889798
 Drug Info Phase 2 Keratoconjunctivitis sicca ICD11: 9A79 [1]
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          2 Drugs
TRP-01
 Drug Info Phase 1 Depression ICD11: 6A71 [3]
BRN-0498823
 Drug Info Phase 1 Essential hypertension ICD11: BA00 [1]
      Discontinued/withdrawn Drugs Click to Show/Hide the Full List of Drugs:          1 Drugs
Levamisole
 Drug Info Discontinued Ascariasis ICD11: 1F62 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          4 Drugs
QC-1571
 Drug Info Preclinical Chronic laryngitis ICD11: CA0G [1]
ML-236B
 Drug Info Preclinical Hypertriglyceridaemia ICD11: 5C80 [1]
L-tyrosine
 Drug Info Investigative Phenylketonuria ICD11: 5C50 [3]
Diacetamate
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
2 In vitro susceptibility of cultured human methanogens to lovastatin. Int J Antimicrob Agents. 2017 Feb;49(2):176-182.
3 Major phenylpropanoid-derived metabolites in the human gut can arise from microbial fermentation of protein. Mol Nutr Food Res. 2013 Mar;57(3):523-35.

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