Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2266)
Drug Name
Biperiden
Synonyms
Beperiden; Biperiden (JAN/USP/INN); Biperiden [USAN:BAN:INN:JAN]; Biperiden [USAN:INN:BAN:JAN]; Biperidene; Biperidene hydrochloride; Biperideno; Biperideno [INN-Spanish]; Biperidenum; Biperidenum [INN-Latin]; Biperidine; Akineton; KL 373; 1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol; 1-(Bicyclo(2.2.1)hept-5-en-2alpha-yl)-1-phenyl-3-piperidinopropanol; 1-(bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol; 1-Bicycloheptenyl-1-phenyl-3-piperidino-propanol-1; 1-Piperidinepropanol, .alpha.-bicyclo[2.2.1]hept-5-en-2-yl-.alpha.-phenyl-, hydrochloride; 3-Piperidino-1-phenyl-1-bicyclo(2.2.1)hepten-(5)-yl-propanol-(1); 3-Piperidino-1-phenyl-1-bicyclo(2.2.1)hepten-(5)-yl-propanol-(1) [German]; 3-Piperidino-1-phenyl-1-bicycloheptenyl-1-propanol; Akineton (TN);Biperidene [INN-French]; Alpha-(Bicyclo(2.2.1)hept-5-en-2-yl)-alpha-phenyl-1-piperidino propanol; Alpha-5-Norbornen-2-yl-alpha-phenyl-1-piperidinepropanol; Alpha-Bicyclo(2.2.1)hept-5-en-2-yl-alpha-phenyl-1-piperidinepropanol; Alpha-bicyclo[2.2.1]hept-5-en-2-yl-alpha-phenyl-1-piperidinepropanol
Indication Parkinsonism [ICD11: 8A00] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 311.5 Topological Polar Surface Area 23.5
Heavy Atom Count 23 Rotatable Bond Count 5
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 2
Cross-matching ID
PubChem CID
2381
PubChem SID
10143 ; 5493029 ; 7847844 ; 8151597 ; 10524841 ; 11456991 ; 11466530 ; 11467650 ; 11486080 ; 14752229 ; 29221547 ; 46508325 ; 47275123 ; 47720190 ; 48317976 ; 50017052 ; 53788571 ; 57321294 ; 76693621 ; 85209894 ; 90341640 ; 92308107 ; 92729934 ; 103024637 ; 103304259 ; 104098413 ; 104300422 ; 124894170 ; 124894171 ; 126688938 ; 129843440 ; 134338370 ; 134978790 ; 137248602 ; 143201313 ; 144075883 ; 160964152 ; 163409099 ; 163847731 ; 174006780 ; 175267713 ; 175611146 ; 178103704 ; 179225300 ; 206246485 ; 210274830 ; 210280462 ; 223672012 ; 223889014 ; 226421316
ChEBI ID
CHEBI:3112
CAS Number
514-65-8
TTD Drug ID
D0B4TN
Formula
C21H29NO
Canonical SMILES
C1CCN(CC1)CCC(C2CC3CC2C=C3)(C4=CC=CC=C4)O
InChI
1S/C21H29NO/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2
InChIKey
YSXKPIUOCJLQIE-UHFFFAOYSA-N
The Predicted Metabolic Roadmap of This Drug
The Full List of Predicted Drug Metabolites (PDM) of This Drug
PDM Name PDM ID PubChem ID Reaction PDM Level Biosystem
Biperiden M1 PDM007136 N. A. Conjugation - Alkyl-OH-glucuronidation 1 Human
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Unclear metabolic mechanism (DME-unclear) DME1365 Bacteroides dorei Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1384 Bacteroides vulgatus Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1393 Blautia hansenii Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1402 Clostridium botulinum Not Available Not Available [2]
References
1 Biperiden was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.

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