Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2282)
Drug Name
Dipyridamole
Synonyms
Dipiridamol; Dipiridamol [INN-Spanish]; Dipyramidole; Dipyridamine; Dipyridamol; Dipyridamole (JP15/USP/INN); Dipyridamole [USAN:INN:BAN:JAN]; Dipyridamolum; Dipyridamolum [INN-Latin]; Dipyridan; Dipyudamine; Dypyridamol; Gulliostin; IPRAD Brand of Dipyridamole; Iv Persantine; Justpertin; Kurantil; Miosen; Novo-Dipiradol; Novopharm Brand of Dipyridamole; Peridamol; Permiltin; Persantin; Persantine; Persantine (TN); Piroan; Prandiol; Prandiol 75; Protangix; Stenocardil; Agilease; Anginal; Antistenocardin; Apo-Dipyridamole; Apo-Dipyridamole Fc; Apo-Dipyridamole Sc; Apotex Brand of Dipyridamole; Apricor; Ashbourne Brand of Dipyridamole; Belmac Brand of Dipyridamole; Cardioflux; Cardoxil; Cardoxin; Cerebrovase; Chilcolan; Cleridium; Cleridium 150; Coribon; Coridil; Coronarine; Corosan; Coroxin; Curantil; Curantyl; Stenocardiol; Stimolcardio; Usaf Ge-12; 2,6-Bis(diethanolamine)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine; 2,6-Bis(diethanolamino)-4,8-dipiperidinopyrimido(5,4-d)pyrimidine; 2,6-Bis(diethanolamino)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine; Berlin Chemie Brand of Dipyridamole; Berlin-Chemie Brand of Dipyridamole; Boehringer Ingelheim Brand of Dipyridamole; D 9766; Natyl; Permole, Persantine, Dipyridan, Dipyridamole; RA-8
Indication Atherosclerosis [ICD11: BA80] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 504.6 Topological Polar Surface Area 145
Heavy Atom Count 36 Rotatable Bond Count 12
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 12
Cross-matching ID
PubChem CID
3108
PubChem SID
480294 ; 489152 ; 612448 ; 855977 ; 5052822 ; 7847368 ; 7979106 ; 8149314 ; 8151978 ; 10321246 ; 10528232 ; 10589644 ; 11111116 ; 11111117 ; 11113358 ; 11335871 ; 11361110 ; 11363898 ; 11366460 ; 11369022 ; 11371244 ; 11374262 ; 11377184 ; 11410079 ; 11462082 ; 11466170 ; 11467290 ; 11484739 ; 11485919 ; 11488788 ; 11490218 ; 11492337 ; 11494818 ; 12054904 ; 14811101 ; 17405027 ; 22391481 ; 24277705 ; 26611713 ; 26680947 ; 26747068 ; 26747069 ; 26751580 ; 26751581 ; 26758633 ; 29222251 ; 46487910 ; 46506292 ; 47291146 ; 47291147
ChEBI ID
ChEBI:4653
CAS Number
58-32-2
TTD Drug ID
D0F9GE
Formula
C24H40N8O4
Canonical SMILES
C1CCN(CC1)C2=NC(=NC3=C2N=C(N=C3N4CCCCC4)N(CCO)CCO)N(CCO)CCO
InChI
1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2
InChIKey
IZEKFCXSFNUWAM-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Monoglucuronide Dipyridamole DM000111 N. A. Conjugation - Conjugation 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR000879 Dipyridamole Monoglucuronide Dipyridamole Conjugation - Conjugation Unclear [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Unclear metabolic mechanism (DME-unclear) DME1365 Bacteroides dorei Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1393 Blautia hansenii Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1402 Clostridium botulinum Not Available Not Available [2]
References
1 Dipyridamole was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
3 LABEL:SPIRIN AND DIPYRIDAMOLE capsule, extended release

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