Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2283)
Drug Name
Ethopropazine
Synonyms
Ethapropazine; Ethopromazine; Etopropezina; Fempropazine; Fenpropazina; Isopthazine; Isotazin; Isothazine; Isothiazine; Lysivane; Parcidol; Pardidol; Parfezine; Parkin; Parkin (TN); Parkisol; Parsidan; Parsidan (TN); Parsidol; Parsidol(TN); Aethopropropazin; Athapropazine; Athopropazin; Parsitan; Parsotil; Phenopropazine; Phenoprozine; Prodictazin; Prodierazine; Profenamina; Profenamina [INN-Spanish]; Profenamina [Italian]; Profenamine; Profenamine (INN); Profenamine [INN:BAN]; Profenaminum; Profenaminum [INN-Latin]; Prophenamine; Prophenaminum; RP 3356; Rochipel; Rocipel; Rodipal; SC 2538; SKF 2538; 10-(2-Diethylaminopropyl)phenothiazine; 10-[2-(Diethylamino)-1-Propyl]phenothiazine;10-[2-(Diethylamino)-2-methylethyl]phenothiazine; 10-[2-(Diethylamino)propyl]phenothiazine; 2-Diethylamino-1-propyl-N-dibenzoparathiazine; N,N-Diethyl-1-(10H-phenothiazin-10-yl)-2-propanamine; N,N-Diethyl-alpha-methyl-10H-phenothiazine-10-ethanamine; N,N-diethyl-1-(10H-phenothiazin-10-yl)propan-2-amine; N,N-diethyl-1-phenothiazin-10-ylpropan-2-amine; W 483
Indication Parkinsonism [ICD11: 8A00] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 312.5 Topological Polar Surface Area 31.8
Heavy Atom Count 22 Rotatable Bond Count 5
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 3
Cross-matching ID
PubChem CID
3290
PubChem SID
5235096 ; 8152090 ; 10525152 ; 11335236 ; 11360475 ; 11363709 ; 11366271 ; 11368833 ; 11371338 ; 11374354 ; 11376995 ; 11455619 ; 11461447 ; 11466868 ; 11467988 ; 11484783 ; 11486456 ; 11488800 ; 11490245 ; 11492363 ; 11494629 ; 14923459 ; 29222428 ; 46507375 ; 46509734 ; 47365017 ; 47365018 ; 47959566 ; 48034942 ; 48110291 ; 48184832 ; 48334311 ; 48415977 ; 49698862 ; 50006444 ; 57244628 ; 57321707 ; 77111137 ; 85209984 ; 85505762 ; 87692421 ; 90341779 ; 96025112 ; 103362582 ; 104303077 ; 125672985 ; 126718928 ; 134338364 ; 134977403 ; 137138734
ChEBI ID
CHEBI:313639
CAS Number
1094-08-2
TTD Drug ID
D0Q0RC
Formula
C19H24N2S
Canonical SMILES
CCN(CC)C(C)CN1C2=CC=CC=C2SC3=CC=CC=C31
InChI
1S/C19H24N2S/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21/h6-13,15H,4-5,14H2,1-3H3
InChIKey
CDOZDBSBBXSXLB-UHFFFAOYSA-N
The Predicted Metabolic Roadmap of This Drug
The Full List of Predicted Drug Metabolites (PDM) of This Drug
PDM Name PDM ID PubChem ID Reaction PDM Level Biosystem
Ethopropazine M1 PDM007174 N. A. Conjugation - N-Glucuronidation of tertiary aliphatic amine 1 Human
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Unclear metabolic mechanism (DME-unclear) DME1365 Bacteroides dorei Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1384 Bacteroides vulgatus Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1393 Blautia hansenii Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1402 Clostridium botulinum Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1444 Odoribacter splanchnicus Not Available Not Available [2]
References
1 Ethopropazine was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.

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