Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR5349)
Drug Name
Tivozanib
Synonyms ASP4130/AV-951
Indication Renal cell carcinoma [ICD11: 2C90] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 454.9 Topological Polar Surface Area 108
Heavy Atom Count 32 Rotatable Bond Count 6
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 7
Cross-matching ID
PubChem CID
9911830
ChEBI ID
CHEBI:91327
CAS Number
475108-18-0
TTD Drug ID
D0W7JZ
Formula
C22H19ClN4O5
Canonical SMILES
CC1=CC(=NO1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)Cl
InChI
InChI=1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28)
InChIKey
SPMVMDHWKHCIDT-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Tivozanib Metabolite M29 DM018272 N. A. Unclear - Unclear 1 [3]
Tivozanib Metabolite M35 DM018273 N. A. Unclear - Unclear 1 [3]
Tivozanib Metabolite M37 DM018275 N. A. Unclear - Unclear 1 [3]
Tivozanib Metabolite M40 DM018274 N. A. Unclear - Unclear 1 [3]
Tivozanib Metabolite M42 DM018276 N. A. Unclear - Unclear 1 [3]
Tivozanib Metabolite M7 DM018277 N. A. Unclear - Unclear 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR010231 Tivozanib Tivozanib Metabolite M29 Unclear - Unclear Unclear [3]
MR010232 Tivozanib Tivozanib Metabolite M35 Unclear - Unclear Unclear [3]
MR010233 Tivozanib Tivozanib Metabolite M40 Unclear - Unclear Unclear [3]
MR010234 Tivozanib Tivozanib Metabolite M37 Unclear - Unclear Unclear [3]
MR010235 Tivozanib Tivozanib Metabolite M42 Unclear - Unclear Unclear [3]
MR010236 Tivozanib Tivozanib Metabolite M7 Unclear - Unclear Unclear [3]
⏷ Show the Full List of 6 MR(s)
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 1A1 (CYP1A1) DME0006 Homo sapiens
CP1A1_HUMAN
1.14.14.1
[2]
Cytochrome P450 3A4 (CYP3A4) DME0001 Homo sapiens
CP3A4_HUMAN
1.14.14.55
[2]
References
1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services
2 Brain accumulation of tivozanib is restricted by ABCB1 (P-glycoprotein) and ABCG2 (breast cancer resistance protein) in mice
3 Absorption, Metabolism, and Excretion of [(14) C]-Tivozanib, a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Healthy Male Participants: A Phase I, Open-Label, Mass-Balance Study

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