Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000001)
Formula
SVG example
Deamination
Reactant Abacavir monophosphate Product Carbovir monophosphate
Reactant Info Product Info
Metabolic Type Oxidation - Deamination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000003 Abacavir Abacavir monophosphate Other reaction - Phosphorylation Abacavir [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000002 Carbovir monophosphate Carbovir triphosphate Other reaction - Phosphorylation Abacavir [1], [2]
References
1 A review of the pharmacokinetics of abacavir. Clin Pharmacokinet. 2008;47(6):351-71.
2 Abacavir Increases Purinergic P2X7 Receptor Activation by ATP: Does a Pro-inflammatory Synergism Underlie Its Cardiovascular Toxicity?. Front Pharmacol. 2021 Mar 31;12:613449. doi: 10.3389/fphar.2021.613449.

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