Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000003)
Formula
ADK
SVG example
Phosphorylation
Reactant Abacavir Product Abacavir monophosphate
Reactant Info Product Info
Metabolic Enzyme Adenosine kinase (ADK) DME Info
Metabolic Type Other reaction - Phosphorylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000006 Abacavir 1144U88 Unclear Abacavir [1]
MR000004 Abacavir 2269W93(Carboxylate) Oxidation - Oxidation Abacavir [2]
MR000005 Abacavir 361W94(glucuronide) Conjugation - Glucuronidation Abacavir [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000001 Abacavir monophosphate Carbovir monophosphate Oxidation - Deamination Abacavir [4]
References
1 Pharmacokinetics of [(14)C]abacavir, a human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitor, administered in a single oral dose to HIV-1-infected adults: a mass balance study Antimicrob Agents Chemother. 1999 Dec;43(12):2855-61. doi: 10.1128/AAC.43.12.2855.
2 The metabolic activation of abacavir by human liver cytosol and expressed human alcohol dehydrogenase isozymes Chem Biol Interact. 2002 Nov 10;142(1-2):135-54. doi: 10.1016/s0009-2797(02)00059-5.
3 Product characteristics of Triumeq
4 A review of the pharmacokinetics of abacavir. Clin Pharmacokinet. 2008;47(6):351-71.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.