Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000015)
Formula	Reactant	ACP-5530	Product	ACP-5531
Formula	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Conjugation - Conjugation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Produce The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR000022	Acalabrutinib	ACP-5530	Conjugation - Glutathione Conjugation	Acalabrutinib	[1]

Other MR(s) Related to The Product of This MR

Other MR(s) That Metabolize The Produtc of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR000016	ACP-5531	ACP-5461	Oxidation - N-Dealkylation	Acalabrutinib	[1]

References
1	Bioavailability, Biotransformation, and Excretion of the Covalent Bruton Tyrosine Kinase Inhibitor Acalabrutinib in Rats, Dogs, and Humans Drug Metab Dispos. 2019 Feb;47(2):145-154. doi: 10.1124/dmd.118.084459.

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