Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000016)
Formula Reactant ACP-5531 Product ACP-5461
Reactant Info Product Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000015 ACP-5530 ACP-5531 Conjugation - Conjugation Acalabrutinib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000146 Almotriptan malate metabolite M3 ACP-5461 Other reaction - Tautomerisation Almotriptan malate [2]
MR001006 SCH 57871 ACP-5461 Oxidation - Oxidation Ezetimibe [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000147 ACP-5461 LAS 31911 Other reaction - Dehydration Almotriptan malate [2]
References
1 Bioavailability, Biotransformation, and Excretion of the Covalent Bruton Tyrosine Kinase Inhibitor Acalabrutinib in Rats, Dogs, and Humans Drug Metab Dispos. 2019 Feb;47(2):145-154. doi: 10.1124/dmd.118.084459.
2 Clinical pharmacokinetics of almotriptan, a serotonin 5-HT(1B/1D) receptor agonist for the treatment of migraine. Clin Pharmacokinet. 2005;44(3):237-46.
3 Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions. Clin Pharmacokinet. 2005;44(5):467-94.

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