Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000047)
Formula
GSTM1 ...
SVG example
Conjugation
Reactant NAPQI Product Acetaminophen cysteine
Reactant Info Product Info
Metabolic Enzyme Glutathione S-transferase mu-1 (GSTM1) DME Info
Glutathione S-transferase theta-1 (GSTT1) DME Info
Glutathione S-transferase pi (GSTP1) DME Info
Metabolic Type Conjugation - Conjugation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000050 Acetaminophen NAPQI Oxidation - Oxidation Acetaminophen [1], [2]
MR002014 Acetaminophen NAPQI Oxidation - Oxidation Phenacetin [3]
References
1 Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents FASEB J. 2010 Dec;24(12):4904-16. doi: 10.1096/fj.10-162438.
2 Rapid detection and quantification of paracetamol and its major metabolites using surface enhanced Raman scattering. Analyst. 2023 Apr 11;148(8):1805-1814. doi: 10.1039/d3an00249g.
3 DrugBank(Pharmacology-Metabolism)Phenacetin

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