Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000050)
Formula
CYP2E1 ...
SVG example
Oxidation
Reactant Acetaminophen Product NAPQI
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2E1 (CYP2E1) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 2A6 (CYP2A6) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000048 Acetaminophen Acetaminophen glucuronide Conjugation - Glucuronidation Acetaminophen [1], [2], [3]
MR000049 Acetaminophen Acetaminophen sulfate Conjugation - Sulfation Acetaminophen [1], [2], [3]
MR002012 Acetaminophen Acetaminophen glucuronide Conjugation - Glucuronidation Phenacetin [4]
MR002013 Acetaminophen Acetaminophen sulfate Unclear Phenacetin [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000047 NAPQI Acetaminophen cysteine Conjugation - Conjugation Acetaminophen [1], [5], [2]
MR002009 NAPQI Acetaminophen cysteine Conjugation - Conjugation Phenacetin [4]
References
1 Simultaneous quantification of abemaciclib and its active metabolites in human and mouse plasma by UHPLC-MS/MS J Pharm Biomed Anal. 2021 Sep 5;203:114225. doi: 10.1016/j.jpba.2021.114225.
2 Application of a Volumetric Absorptive Microsampling (VAMS)-Based Method for the Determination of Paracetamol and Four of its Metabolites as a Tool for Pharmacokinetic Studies in Obese and Non-Obese Patients. Clin Pharmacokinet. 2022 Dec;61(12):1719-1733. doi: 10.1007/s40262-022-01187-2.
3 Evaluation of urinary acetaminophen metabolites and its association with the genetic polymorphisms of the metabolising enzymes, and serum acetaminophen concentrations in preterm neonates with patent ductus arteriosus. Xenobiotica. 2021 Nov;51(11):1335-1342. doi: 10.1080/00498254.2021.1982070.
4 DrugBank(Pharmacology-Metabolism)Phenacetin
5 Detection of Distinct Distributions of Acetaminophen and Acetaminophen-Cysteine in Kidneys up to 10 m Resolution and Identification of a Novel Acetaminophen Metabolite Using an AP-MALDI Imaging Mass Microscope. J Am Soc Mass Spectrom. 2023 Jun 12. doi: 10.1021/jasms.3c00149.

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