Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000111)
Formula
SVG example
Hydroxylation
Reactant Albendazole Product Hydroxyalbendazole
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2J2 (CYP2J2) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000109 Albendazole (+) albendazole sulfoxide Oxidation - Oxidation Albendazole [1], [2], [3], [4]
MR000110 Albendazole (-) albendazole sulfoxide Oxidation - Oxidation Albendazole [1], [2], [3], [4]
MR000112 Albendazole . Oxidation - Oxidation Albendazole [5]
References
1 Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY:McGraw-Hill, 2001., p. 1126
2 Nanocrystal Suspensions for Enhancing the Oral Absorption of Albendazole. Nanomaterials (Basel). 2022 Sep 1;12(17):3032. doi: 10.3390/nano12173032.
3 Multi-residue methodology for quantification of antiparasitics in hen eggs by LC-MS/MS: development, validation and application to 348 samples from Brazil. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2022 Aug;39(8):1412-1423. doi: 10.1080/19440049.2022.2093984.
4 Improvement of Albendazole Bioavailability with Menbutone Administration in Sheep. Animals (Basel). 2022 Feb 14;12(4):463. doi: 10.3390/ani12040463.
5 Effect of clotrimazole on microsomal metabolism and pharmacokinetics of albendazole J Pharm Pharmacol. 2003 Jun;55(6):757-64. doi: 10.1211/002235703765951357.

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