Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000147)
Formula
SVG example
Dehydration
Reactant ACP-5461 Product LAS 31911
Reactant Info Product Info
Metabolic Enzyme Aldehyde dehydrogenase 1 (ALDH1) DME Info
Metabolic Type Other reaction - Dehydration
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000146 Almotriptan malate metabolite M3 ACP-5461 Other reaction - Tautomerisation Almotriptan malate [1]
MR001006 SCH 57871 ACP-5461 Oxidation - Oxidation Ezetimibe [2]
MR000016 ACP-5531 ACP-5461 Oxidation - N-Dealkylation Acalabrutinib [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000151 LAS 31911 Almotriptan malate metabolite P13 Oxidation - N-Demethylation Almotriptan malate [4]
MR000150 LAS 31911 Almotriptan malate metabolite P5 Oxidation - Hydroxylation Almotriptan malate [4]
MR000149 LAS 31911 Almotriptan malate metabolite P6 Oxidation - N-Dealkylation Almotriptan malate [4]
MR000148 LAS 31911 Almotriptan malate metabolite P9 Oxidation - Hydroxylation Almotriptan malate [4]
References
1 Clinical pharmacokinetics of almotriptan, a serotonin 5-HT(1B/1D) receptor agonist for the treatment of migraine. Clin Pharmacokinet. 2005;44(3):237-46.
2 Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions. Clin Pharmacokinet. 2005;44(5):467-94.
3 Bioavailability, Biotransformation, and Excretion of the Covalent Bruton Tyrosine Kinase Inhibitor Acalabrutinib in Rats, Dogs, and Humans Drug Metab Dispos. 2019 Feb;47(2):145-154. doi: 10.1124/dmd.118.084459.
4 Disposition and metabolism of almotriptan in rats, dogs and monkeys Xenobiotica. 2006 Sep;36(9):807-23. doi: 10.1080/00498250600802508.

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