Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000245)
Formula
SVG example
Sulfation
Reactant Apixaban M2 metabolite Product Apixaban M1 metabolite
Reactant Info Product Info
Metabolic Enzyme Sulfotransferase 1A1 (SULT1A1) DME Info
Metabolic Type Conjugation - Sulfation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000248 Apixaban Apixaban M2 metabolite Oxidation - O-Demethylation Apixaban [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000244 Apixaban M2 metabolite Apixaban M13 metabolite Oxidation - Hydroxylation Apixaban [3]
References
1 Apixaban. Hosp Pharm. 2013 Jun;48(6):494-509.
2 Apixaban. After hip or knee replacement: LMWH remains the standard treatment. Prescrire Int. 2012 Sep;21(130):201-2, 204.
3 Apixaban metabolism and pharmacokinetics after oral administration to humans Drug Metab Dispos. 2009 Jan;37(1):74-81. doi: 10.1124/dmd.108.023143.

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