Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000248)
Formula
CYP1A2 ...
SVG example
O-Demethylation
Reactant Apixaban Product Apixaban M2 metabolite
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2J2 (CYP2J2) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - O-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000249 Apixaban Apixaban M4/7 metabolite Oxidation - Hydroxylation Apixaban [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000245 Apixaban M2 metabolite Apixaban M1 metabolite Conjugation - Sulfation Apixaban [3], [4]
MR000244 Apixaban M2 metabolite Apixaban M13 metabolite Oxidation - Hydroxylation Apixaban [4]
References
1 Apixaban. Hosp Pharm. 2013 Jun;48(6):494-509.
2 Apixaban. After hip or knee replacement: LMWH remains the standard treatment. Prescrire Int. 2012 Sep;21(130):201-2, 204.
3 Sulfation of o-demethyl apixaban: enzyme identification and species comparison. Drug Metab Dispos. 2009 Apr;37(4):802-8. doi: 10.1124/dmd.108.025593.
4 Apixaban metabolism and pharmacokinetics after oral administration to humans Drug Metab Dispos. 2009 Jan;37(1):74-81. doi: 10.1124/dmd.108.023143.

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