Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000253)
Formula
SVG example
Oxidation
Reactant Apomorphine Product O-quinone
Reactant Info Product Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000251 Apomorphine Apocodeine Conjugation - O-Methylation Apomorphine [1]
MR000250 Apomorphine Apocodeine sulfate Conjugation - Conjugation Apomorphine [2], [1]
MR000254 Apomorphine Apomorphine 10-glucuronide Conjugation - O-Glucuronidation Apomorphine [3]
MR000255 Apomorphine Apomorphine 11-glucuronide Conjugation - O-Glucuronidation Apomorphine [3]
MR000252 Apomorphine Isoapocodeine Conjugation - O-Methylation Apomorphine [1]
MR000256 Apomorphine Norapomorphine Oxidation - N-Demethylation Apomorphine [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007624 Pyrocatechol O-quinone Unclear Pyrocatechol [5]
MR009202 3-(Dihydroxyphenyl)propanoic acid O-quinone Unclear - Unclear 3,4-Dihydroxycinnamic Acid [6]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007625 O-quinone Unclear Conjugation - Conjugation Pyrocatechol [5]
References
1 Pharmacokinetics, enantiomer interconversion, and metabolism of R-apomorphine in patients with idiopathic Parkinson's disease Clin Neuropharmacol. 1998 May-Jun;21(3):159-68.
2 Sulfation of apomorphine by human sulfotransferases: evidence of a major role for the polymorphic phenol sulfotransferase, SULT1A1. Xenobiotica. 2003 Nov;33(11):1139-48.
3 Glucuronidation of apomorphine Life Sci. 2000 Aug 25;67(14):1735-45. doi: 10.1016/s0024-3205(00)00764-5.
4 The pharmacology and clinical pharmacokinetics of apomorphine SL BJU Int. 2001 Oct;88 Suppl 3:18-21. doi: 10.1046/j.1464-4096.2001.00124.x.
5 Assessment of the metabolism and intrinsic reactivity of a novel catechol metabolite
6 Metabolism of caffeic acid by isolated rat hepatocytes and subcellular fractions

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