Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000280)
Formula Reactant Apremilast Product Apremilast metabolite M5
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000277 Apremilast Apremilast metabolite M1/2 Unclear Apremilast [1]
MR000278 Apremilast Apremilast metabolite M17 Oxidation - Hydroxylation Apremilast [1]
MR000279 Apremilast Apremilast metabolite M7 Oxidation - N-Deacetylation Apremilast [1]
MR000276 Apremilast O-desmethyl Apremilast Oxidation - O-Demethylation Apremilast [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000275 Apremilast metabolite M5 Apremilast metabolite M13 Conjugation - Glucuronidation Apremilast [1]
MR000273 Apremilast metabolite M5 Apremilast metabolite M19 Hydrolysis - Hydrolysis Apremilast [1]
MR000274 Apremilast metabolite M5 Apremilast metabolite M22 Hydrolysis - Hydrolysis Apremilast [1]
References
1 Disposition, metabolism and mass balance of [(14)C]apremilast following oral administration. Xenobiotica. 2011 Dec;41(12):1063-75.

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