Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000334)
Formula
SVG example
6-Hydroxylation
Reactant Desmethylastemizole Product 6-hydroxydesmethylastemizole
Reactant Info Product Info
Metabolic Type Oxidation - 6-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006262 Desmethylastemizole CO-glucuronide Conjugation - Glucuronidation Desmethylastemizole [1]
MR006261 Desmethylastemizole Norastemizole Oxidation - N-Dealkylation Desmethylastemizole [1]
MR000335 Desmethylastemizole Tecastemizole Oxidation - N-Dealkylation Astemizole [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000330 6-hydroxyastemizole 6-hydroxydesmethylastemizole Oxidation - O-Demethylation Astemizole [1]
References
1 Involvement of multiple human cytochromes P450 in the liver microsomal metabolism of astemizole and a comparison with terfenadine. Br J Clin Pharmacol. 2001 Feb;51(2):133-42.

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