General Information of This Metabolic Reaction (MR) (ID:
MR000330) |
Formula |
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Reactant |
6-hydroxyastemizole |
Product |
6-hydroxydesmethylastemizole |
Reactant Info
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Product Info
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Metabolic Enzyme
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Cytochrome P450 3A43 (CYP3A43)
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DME Info
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Metabolic Type
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Oxidation
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O-Demethylation
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Other MR(s) Related to The Reactant of This MR |
Other MR(s) That Produce The Reactant of This MR
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Other MR(s) Related to The Product of This MR |
Other MR(s) That Produce The Product of This MR
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References |
1 |
Involvement of multiple human cytochromes P450 in the liver microsomal metabolism of astemizole and a comparison with terfenadine. Br J Clin Pharmacol. 2001 Feb;51(2):133-42.
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