General Information of This Metabolic Reaction (MR) (ID: MR000330)
Formula
SVG example
O-Demethylation
Reactant 6-hydroxyastemizole Product 6-hydroxydesmethylastemizole
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A43 (CYP3A43) DME Info
Metabolic Type Oxidation - O-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000331 Astemizole 6-hydroxyastemizole Oxidation - Hydroxylation Astemizole [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006260 Desmethylastemizole 6-Hydroxydesmethylastemizole Oxidation - 6-Hydrolyzationn Desmethylastemizole [1]
MR000334 Desmethylastemizole 6-hydroxydesmethylastemizole Oxidation - 6-Hydroxylation Astemizole [1]
References
1 Involvement of multiple human cytochromes P450 in the liver microsomal metabolism of astemizole and a comparison with terfenadine. Br J Clin Pharmacol. 2001 Feb;51(2):133-42.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.