Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000390)
Formula
SVG example
Hydroxylation
Reactant BMS-650032 Product Asunaprevir metabolite M8
Reactant Info Product Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000392 BMS-650032 Asunaprevir metabolite M10 Hydrolysis - Hydrolysis BMS-650032 [1], [2]
MR000395 BMS-650032 Asunaprevir metabolite M15 Unclear BMS-650032 [1], [2]
MR000393 BMS-650032 Asunaprevir metabolite M2 Hydrolysis - Hydrolysis BMS-650032 [1], [2]
MR000394 BMS-650032 Asunaprevir metabolite M3,5,7 Oxidation - Monohydroxylation BMS-650032 [1], [2]
MR000389 BMS-650032 Asunaprevir metabolite M6 Oxidation - O-Demethylation BMS-650032 [1], [2]
MR000391 BMS-650032 BMS-798430 Reduction - Reduction BMS-650032 [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000386 Asunaprevir metabolite M8 Asunaprevir metabolite M11,19,20 Oxidation - Hydroxylation BMS-650032 [1], [2]
References
1 Effect of CYP3A5*3 genetic variant on the metabolism of direct-acting antivirals in vitro: a different effect on asunaprevir versus daclatasvir and beclabuvir J Hum Genet. 2020 Jan;65(2):143-153. doi: 10.1038/s10038-019-0685-2.
2 DrugBank(Pharmacology-Metabolism)Asunaprevir

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