Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000403)
Formula
SVG example
Hydoxylation
Reactant Bortezomib metabolite M2 Product Bortezomib metabolite M8
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydoxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000409 Bortezomib Bortezomib metabolite M2 Oxidation - Oxidation; Deboronation Bortezomib [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000405 Bortezomib metabolite M2 Bortezomib metabolite M27 Oxidation - Hydoxylation Bortezomib [1]
MR000404 Bortezomib metabolite M2 Bortezomib metabolite M28 Oxidation - Hydoxylation Bortezomib [1]
MR000402 Bortezomib metabolite M2 Bortezomib metabolite M3 Hydrolysis - Hydrolysis Bortezomib [1]
MR000406 Bortezomib metabolite M2 Bortezomib metabolite M6 Oxidation - Hydoxylation Bortezomib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000407 Bortezomib metabolite M8 Bortezomib metabolite M33 Unclear Bortezomib [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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