Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000550)
Formula
SVG example
Hydroxylation
Reactant Canagliflozin Product Canagliflozin metabolite M9
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000549 Canagliflozin Canagliflozin metabolite M5 Conjugation - O-Glucuronidation Canagliflozin [1]
MR000548 Canagliflozin Canagliflozin metabolite M7 Conjugation - O-Glucuronidation Canagliflozin [1]
References
1 Clinical Pharmacokinetic, Pharmacodynamic, and Drug-Drug Interaction Profile of Canagliflozin, a Sodium-Glucose Co-transporter 2 Inhibitor Clin Pharmacokinet. 2015 Oct;54(10):1027-41. doi: 10.1007/s40262-015-0285-z.

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