Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000583)
Formula
SVG example
Deacetylation
Reactant Cefotaxime Product Desacetyl-cefotaxime
Reactant Info Product Info
Metabolic Enzyme Beta-lactamase (blaB) DME Info
Metabolic Type Oxidation - Deacetylation
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011857 Ro-23-9424 Desacetylcefotaxime Unclear - Unclear Ro-23-9424 [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000580 Desacetyl-cefotaxime Deacetylcefotaxime lactone Unclear Cefotaxime [2], [3]
References
1 Pharmacokinetics of Ro 23-9424, a dual-action cephalosporin, in animals
2 Metabolism of cefotaxime in animals and humans Rev Infect Dis. 1982 Sep-Oct;4 Suppl:S325-32. doi: 10.1093/clinids/4.supplement_2.s325.
3 Molecularly Imprinted Polymers as Solid-Phase Microextraction Fibers for the Isolation of Selected Antibiotics from Human Plasma. Materials (Basel). 2021 Aug 27;14(17):4886. doi: 10.3390/ma14174886.

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