Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000585)
Formula
ADH1A ...
SVG example
Reactant Hydroxycelecoxib Product Carboxycelecoxib
Reactant Info Product Info
Metabolic Enzyme Alcohol dehydrogenase class-I alpha (ADH1A) DME Info
Alcohol dehydrogenase (quinone), cytochrome c subunit (adhB) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000587 Celecoxib Hydroxycelecoxib Oxidation - Hydroxylation Celecoxib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000586 Carboxycelecoxib Celecoxib metabolite M1 Conjugation - Glucuronidation Celecoxib [2]
References
1 Celecoxib pathways: pharmacokinetics and pharmacodynamics. Pharmacogenet Genomics. 2012 Apr;22(4):310-8.
2 Quantitation of celecoxib and four of its metabolites in rat blood by UPLC-MS/MS clarifies their blood distribution patterns and provides more accurate pharmacokinetics profiles J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Sep 15;1001:202-11. doi: 10.1016/j.jchromb.2015.07.026.

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