Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000597)
Formula Reactant Cenobamate Product Cenobamate metabolite M11
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
UDP-glucuronosyltransferase 2B4 (UGT2B4) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000596 Cenobamate Cenobamate metabolite M1 Conjugation - Glucuronidation Cenobamate [1]
MR000599 Cenobamate Cenobamate metabolite M2a/2b Conjugation - Glucuronidation Cenobamate [1]
MR000598 Cenobamate Cenobamate metabolite M3 Conjugation - Glucuronidation Cenobamate [1]
MR000595 Cenobamate Cenobamate metabolite M6/7 Oxidation - Hydroxylation Cenobamate [1]
References
1 Mass Balance, Metabolism, and Excretion of Cenobamate, a New Antiepileptic Drug, After a Single Oral Administration in Healthy Male Subjects Eur J Drug Metab Pharmacokinet. 2020 Aug;45(4):513-522. doi: 10.1007/s13318-020-00615-7.

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