Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000649)
Formula
SVG example
2-Hydroxylation
Reactant Chlorpropamide Product 3-hydroxychlorpropamide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - 2-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000648 Chlorpropamide 2-hydroxychlorpropamide Oxidation - 2-Hydroxylation Chlorpropamide [1]
MR000650 Chlorpropamide 2-OH-chlorpropamide Oxidation - Hydroxylation Chlorpropamide [1]
MR000647 Chlorpropamide 4-Chlorobenzenesulfonylurea Oxidation - N-Dealkylation Chlorpropamide [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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